GACH_DICDI
ID GACH_DICDI Reviewed; 566 AA.
AC Q86IG9; Q559C3;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Rho GTPase-activating protein gacH;
DE AltName: Full=GTPase activating factor for raC protein H;
GN Name=gacH; ORFNames=DDB_G0272694;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC transduction pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AAFI02000008; EAL70984.1; -; Genomic_DNA.
DR RefSeq; XP_644893.1; XM_639801.1.
DR AlphaFoldDB; Q86IG9; -.
DR SMR; Q86IG9; -.
DR STRING; 44689.DDB0233788; -.
DR PaxDb; Q86IG9; -.
DR PRIDE; Q86IG9; -.
DR EnsemblProtists; EAL70984; EAL70984; DDB_G0272694.
DR GeneID; 8618572; -.
DR KEGG; ddi:DDB_G0272694; -.
DR dictyBase; DDB_G0272694; gacH.
DR eggNOG; KOG4270; Eukaryota.
DR HOGENOM; CLU_481856_0_0_1; -.
DR InParanoid; Q86IG9; -.
DR OMA; KYHNDFI; -.
DR PhylomeDB; Q86IG9; -.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-9013148; CDC42 GTPase cycle.
DR Reactome; R-DDI-9013149; RAC1 GTPase cycle.
DR Reactome; R-DDI-9013423; RAC3 GTPase cycle.
DR Reactome; R-DDI-9013424; RHOV GTPase cycle.
DR PRO; PR:Q86IG9; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.
DR GO; GO:0043087; P:regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR Gene3D; 1.10.555.10; -; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasm; GTPase activation; Reference proteome.
FT CHAIN 1..566
FT /note="Rho GTPase-activating protein gacH"
FT /id="PRO_0000380203"
FT DOMAIN 369..564
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 63422 MW; 4656AC71B35171AB CRC64;
MSGVGGESVH LRRSSTTATT TGSSKSSLNI SKSVSPTGNK AVSPMSSPNS LQSGATPTIA
QLQSLLKQQQ QPNHSITTNN NNNKSVSVEI DDLKSQLQHS NINDTFNEDE EIEEVTDEVI
INHDYHSSED EYEDDEDEDE NNNSVNNNSN NNSNNNNNNN TSISSAHSCE SIAEEEELTA
SPILSRQYSY TIGHGTKPDV VLSIGGGFHS SPRSNRSEST IVHEDDLTNQ NDKVINAKDK
ISSDYKRMME DPEAFRNEKL KQRKSKFFTK KDLEEIPFNP SSGTQLRSTL FQQFMNEKIQ
MISENPEKYK SELMKFYKQN LKPQVPKSPQ SSGSLSTHSD KLKTSSSLQR SRSVSQPPVV
TGNSKNAIGS LDTILEKERK RDGNQDRQLP ILFTKCVDFL SNDEALKTEG LFRVAGNSSE
VEDLMKSILL YGSDIPSNCC YHVVSNMLKK FLRQLSTPVF TFKYHNDFIQ TMKLNNDEER
IKAIKEILKL IPPVNQLLIK ELMKFLVKVT SFSNVNMMHA HNLGLMFGPN MLKAPSDSEM
NAISMLDAGN QVITLLIENY NLFYDN
