GACI_DICDI
ID GACI_DICDI Reviewed; 799 AA.
AC Q553X3; Q869Y5;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Rho GTPase-activating protein gacI;
DE AltName: Full=GTPase activating factor for raC protein I;
GN Name=gacI; ORFNames=DDB_G0275185;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC transduction pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AAFI02000013; EAL69873.1; -; Genomic_DNA.
DR RefSeq; XP_643838.1; XM_638746.1.
DR AlphaFoldDB; Q553X3; -.
DR SMR; Q553X3; -.
DR STRING; 44689.DDB0233847; -.
DR PaxDb; Q553X3; -.
DR EnsemblProtists; EAL69873; EAL69873; DDB_G0275185.
DR GeneID; 8619885; -.
DR KEGG; ddi:DDB_G0275185; -.
DR dictyBase; DDB_G0275185; gacI.
DR eggNOG; KOG4270; Eukaryota.
DR HOGENOM; CLU_352132_0_0_1; -.
DR InParanoid; Q553X3; -.
DR OMA; AFQMARI; -.
DR PhylomeDB; Q553X3; -.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-9013148; CDC42 GTPase cycle.
DR Reactome; R-DDI-9013149; RAC1 GTPase cycle.
DR Reactome; R-DDI-9013423; RAC3 GTPase cycle.
DR Reactome; R-DDI-9013424; RHOV GTPase cycle.
DR PRO; PR:Q553X3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0043087; P:regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasm; GTPase activation; Reference proteome.
FT CHAIN 1..799
FT /note="Rho GTPase-activating protein gacI"
FT /id="PRO_0000380205"
FT DOMAIN 226..451
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 472..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..571
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 799 AA; 89039 MW; 1D3AF1B42D5F58A8 CRC64;
MNIKSLRKKN IQNMDQEEVY NRIKENVAHM DEIQRTMEKQ QQTFFQMSLQ SKQIAESMKK
YSMDAAYFNS RIPITDCLSR ASEWQNSISE VFNHLGNLLY DRTTQPLKQT ISIQLEMVKE
GKKKLKNLST DTSKSSSANL KKDTEAFERT QKETLQLYND SELALENSTV QTILSSFESY
NDFFQRGVFQ MSKIKSDIDN YKKIILETNK VAAKLRNYVP KKTFGIKLEE VFARESNKPL
PSFLDEIFRY LEKESINTEG MFRVSAGKSS LEALQQKIES GAPLELSASI IDPHCVSSVL
KLFLRSLPEP LVLYNVYSKY LTVAKNNNNN NNNNNNNISN SSSNLNIVGS SGNNNSGGGS
GGTIITELRR LISTLPVCNQ ALLKQILLIC SLMNQHRDVT KMDLTNLSVV IGPSILEPIP
NLKAEDIQRP ETFADFNSLF CLLVEHVLTI FPQVSQTSMD MASLPTTIGK LRSQSDISSQ
TKPLPSLPTS PQNRSAIITG DSSSPSLNTP PVKSSLNSSD FVIVDNGSNN NNNNNTTNTI
TNNGIADTAT PPPPTTPTAP TTPPPPTTPT SNNIATPIIN INIPNSSNNN NNNNTKRINN
KSNLKVDDYL TPIDMQIYYI NISSNLGRIK SYVDDIETVN QGIGLIKLFK KISDDHMAPI
KNILNYKFKT EKPPMSNDED KVLRIKRTLF YTYEITMELI SHANNTFESS SIEEPTELSK
KLEESFKQLD TILTDELSNI EKQQQQQQQQ TNDGGGSGIS SNTNTSISGD NSENGDSLNS
STSNQSPLNS SILTQLSNQ
