GACK_DICDI
ID GACK_DICDI Reviewed; 970 AA.
AC Q54MI9;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Rho GTPase-activating protein gacK;
DE AltName: Full=GTPase activating factor for raC protein K;
DE Flags: Precursor;
GN Name=gacK; ORFNames=DDB_G0285915;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC transduction pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AAFI02000082; EAL64492.1; -; Genomic_DNA.
DR RefSeq; XP_638001.1; XM_632909.1.
DR AlphaFoldDB; Q54MI9; -.
DR STRING; 44689.DDB0233878; -.
DR PaxDb; Q54MI9; -.
DR EnsemblProtists; EAL64492; EAL64492; DDB_G0285915.
DR GeneID; 8625352; -.
DR KEGG; ddi:DDB_G0285915; -.
DR dictyBase; DDB_G0285915; gacK.
DR eggNOG; KOG4270; Eukaryota.
DR HOGENOM; CLU_305755_0_0_1; -.
DR InParanoid; Q54MI9; -.
DR OMA; QHKLRRD; -.
DR PRO; PR:Q54MI9; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; -; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR044785; RopGAP1-5.
DR PANTHER; PTHR23177; PTHR23177; 2.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasm; GTPase activation; Reference proteome; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..970
FT /note="Rho GTPase-activating protein gacK"
FT /id="PRO_0000380209"
FT DOMAIN 754..970
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 30..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..338
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 970 AA; 105436 MW; 7799D6F18EDC7A2D CRC64;
MTLVYEKSSF VLIMAQIAEA QNIMTRSTSS NDLLSTSAGS PPSPTSAAIL LSSSPSPTIT
IASLPSGLNI VSNPNGNPAI NVVLLNVNLN KEEEKMTLGQ LLACFPEVPS NIPIQLNPNQ
HKLRRDTIVS QPVITSKQSS LFETSKQSNI PLSASVTNLQ TLNKEKENYN LLNSSTNSLH
SLIITPPTSN NTSSNNFVGG NIINSSSEDS ILPPPHIITT TTTTTTSLPP RSPMPLPSSN
CINIPNNINI PDNISESSTC SLSSNASNNY PQSPPKYNNF EINQNNNNSI SLSKSQSLDN
ILTNSNNNNN NEITISSNIP IPLPPQSSSP PPTRNNQSSP SPSSPQQQNI MPTPPSTSLT
PPQSPTLSPS SSTHSTPTQT TTTIKLPPSS PPSTISQNNA RKTQIPTTTT TTTTTTTTTS
TTSTTSPNPV VNNKNLNTPS SSFSPTKRLT IAFGSLTRSS NTPPPESSIV PIRWEINLNQ
IKIASTSTSN TNTVSSQNLI NSSNTNNNNN NNNNNNNNNN NNNNNNNNNN NNNNSGNNNN
NNNNNNNNNN QLYEQYYKLC KGEFQQNTSL YNKTFNQLLD VDINTSLSLL DKCYDSILKS
NGIGLLSSKD QYLSTQSKEK DPNRVKSLLS VVKNAVSEDI LNVKPSKTML YFSNFGKTIP
INLEVIDECI LNNFSSKKVK FKVLMGPPSK THTINVSEKE GFIGKKSSIT LNFSLILKSS
IKLRRVVIIE IEGGVRYFIL VQVESNKTAF GQPIEDSELV EDNTSFGPML VPRALVILKQ
AFFGCNAHLT ESIFRLPPAN DSEYNIVKDR VNREAIGTTE PHCIATLIKV FFRELPNLLL
NDIDPEIFLN FKPTAQSADT ASSAATANSS SSGSGNGNSS PNNDDPTMDP VFIVNLIEEK
RRSTFLWLVD LLAEVTKFES SNKMNSKSLS IIFSPNLYFA PSICSAENSF AISGKVVSFI
LELIQFNKSL
