GACM_DICDI
ID GACM_DICDI Reviewed; 896 AA.
AC Q1ZXE1;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Rho GTPase-activating protein gacM;
DE AltName: Full=GTPase activating factor for raC protein M;
GN Name=gacM; ORFNames=DDB_G0287895;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA Skelton J., Ivens A., Bozzaro S.;
RT "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT bacteria in Dictyostelium.";
RL BMC Genomics 9:291-291(2008).
CC -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC transduction pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- INDUCTION: Down-regulated by phagocytic stimuli.
CC {ECO:0000269|PubMed:18559084}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000104; EAS66846.1; -; Genomic_DNA.
DR RefSeq; XP_001134529.1; XM_001134529.1.
DR AlphaFoldDB; Q1ZXE1; -.
DR SMR; Q1ZXE1; -.
DR STRING; 44689.DDB0233079; -.
DR PaxDb; Q1ZXE1; -.
DR EnsemblProtists; EAS66846; EAS66846; DDB_G0287895.
DR GeneID; 8626347; -.
DR KEGG; ddi:DDB_G0287895; -.
DR dictyBase; DDB_G0287895; gacM.
DR eggNOG; KOG4407; Eukaryota.
DR HOGENOM; CLU_323009_0_0_1; -.
DR InParanoid; Q1ZXE1; -.
DR OMA; IWAYRFL; -.
DR Reactome; R-DDI-9013148; CDC42 GTPase cycle.
DR Reactome; R-DDI-9013149; RAC1 GTPase cycle.
DR PRO; PR:Q1ZXE1; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; -; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; GTPase activation; Reference proteome.
FT CHAIN 1..896
FT /note="Rho GTPase-activating protein gacM"
FT /id="PRO_0000380211"
FT DOMAIN 139..330
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 896 AA; 98231 MW; 337D8E423EF1ABA5 CRC64;
MSSFIGWKKN SNSGGTPGAS PTSSSPLNST ISNANSVSGL GPLGSISNTS SSSLSSSFQP
IQIVNSNNNS PPLSSSSSST STYSTPNSSN DTIGKSSSSS VASAAAAGAS STSTYSSSSS
LIDTSQFNNN YVGNIFGGQP INPNTEFGSS ILNKFSKYLL NKGFNTEGIF KPHPELDNEI
QNVKKNLIKD LSIGDMEQAS LSTLTQNPLV IGEIMKQYLA LLPEPLFSYQ LYDSFLLTHS
ILSPTDRIWA YRFLLLYLPV GFRGAIKSVL GLLSRVHQCS ESSKMNSESL AKIFSPVFLR
PAEDMYYMKS DQSTLEEIVK LWIEEFDMIS KPPTNPNPNS KVTILGTNNT LSQLQQQSNQ
HSSLPNISSL SSNLIQQQLQ QQQQQQQQSH PTIGMSKITS SLSSSSLQVN LQTSPKSPQS
PKLLLPTIPK DDQQQMTIVK QKPILSKPTP TTTPTLTPQT TNPPPVPAST LDNNNSNNNN
NNNNNNSNNN NNNNNNNNNN NNNNNNITPN GSPLINKRLS IGGFALSPPG ASTSFSSLSE
QEVEDKVRKI KVSIDTMVSE QALLLIKNLL KSIEKEFNYN HIIKFSSIIR DAKKHMNESS
EKQLSLTKAN IREFIQEYPK PMSYNLLVSS IPKLDTTNFT EQEKKANDIK RASQVAADEI
SDYIYYFKLK ISTFQLKEQV ISTAQIFSKL KSILESPPPS LPTGSSWSDF ENNSSNNNIN
INNNINNSSS NNNNNNSSPN SSPLMGRLKT SNGLNSSSNS NVTPPTENQI SADKATIRII
EVCSQEIKSR FGSMRSNLER VDINGAFEIG KHSRNVKAVL NDIYVQCKLI PPPDIKALPP
GEDQLTTLRK ALPPLFDRFV TQIDELTQHV FNNKASPEEI TIIVDKLLFI NRSLSM
