ID   GACN_DICDI              Reviewed;         611 AA.
AC   Q54WY8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Rho GTPase-activating protein gacN;
DE   AltName: Full=GTPase activating factor for raC protein N;
GN   Name=gacN; ORFNames=DDB_G0279315;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC       transduction pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AAFI02000030; EAL67806.1; -; Genomic_DNA.
DR   RefSeq; XP_641789.1; XM_636697.1.
DR   AlphaFoldDB; Q54WY8; -.
DR   SMR; Q54WY8; -.
DR   STRING; 44689.DDB0233784; -.
DR   PaxDb; Q54WY8; -.
DR   PRIDE; Q54WY8; -.
DR   EnsemblProtists; EAL67806; EAL67806; DDB_G0279315.
DR   GeneID; 8621986; -.
DR   KEGG; ddi:DDB_G0279315; -.
DR   dictyBase; DDB_G0279315; gacN.
DR   eggNOG; KOG4407; Eukaryota.
DR   HOGENOM; CLU_447207_0_0_1; -.
DR   InParanoid; Q54WY8; -.
DR   OMA; HGKNCNI; -.
DR   PhylomeDB; Q54WY8; -.
DR   PRO; PR:Q54WY8; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0035020; P:regulation of Rac protein signal transduction; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; GTPase activation; Reference proteome.
FT   CHAIN           1..611
FT                   /note="Rho GTPase-activating protein gacN"
FT                   /id="PRO_0000380212"
FT   DOMAIN          24..219
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   REGION          476..550
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          236..499
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        490..537
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   611 AA;  69666 MW;  9C5C021741B4597B CRC64;
     MEPKEGGSPQ ATTLKRNKDK TMAKTFKKIL KPGEKKKKQK AIVIAAIKQL IHYLETNCIE
     LEGICRISGN NTKVKELKKQ LENGEGDSID FSKIDSHCVS GALKAFLRDG DEPLLTFDLY
     KNFLASIDIK DKNSKISFIK SLLSALPKEN YDLLQILLKF LNTIQLHSSI NKMTSSNLAI
     VFSPTLLRPK EESLESMMTD SNSISEVVRV LIEEFHVLYE IKQTLLYQVS AIDLGIREDK
     RSTSEQLEDA KVTIEQLKKH LNEEARERSI LETYCTSMEQ KLQELEDINK SLTEEKDSLG
     ELLNEFKETN KNQANDINSL KNDIKDVTEK QTKTELERDE LNKVKVKLEK DIETTRIELK
     STNDECQKLK VNNNKLGEDI KNQMKEFEQT RKSLLENHKL EFEKHQLEIQ QFRQENEQLK
     KEKTDADLQL ERVQAEISIL LSSSNDKNSK KNSLKNQKKD LDNALKKCKD QESKINQLEK
     EKSKLQDELT KLQKSSSSSS SSSSSSSSSQ ASHKFVFGKK PSSSKITTTT TTTTSPAQQP
     TTPPPPLDED DIISVKKFAF YYMNLAIKTD AMTKGLPCNI NSSEILEELL SKNIKVQQWS
     EVISKKLKEN K