ID   GACP_DICDI              Reviewed;         576 AA.
AC   Q54XE8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Rho GTPase-activating protein gacP;
DE   AltName: Full=GTPase activating factor for raC protein P;
GN   Name=gacP; ORFNames=DDB_G0279009;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC       transduction pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AAFI02000026; EAL67926.1; -; Genomic_DNA.
DR   RefSeq; XP_641902.1; XM_636810.1.
DR   AlphaFoldDB; Q54XE8; -.
DR   SMR; Q54XE8; -.
DR   STRING; 44689.DDB0233789; -.
DR   PaxDb; Q54XE8; -.
DR   PRIDE; Q54XE8; -.
DR   EnsemblProtists; EAL67926; EAL67926; DDB_G0279009.
DR   GeneID; 8621827; -.
DR   KEGG; ddi:DDB_G0279009; -.
DR   dictyBase; DDB_G0279009; gacP.
DR   eggNOG; KOG4270; Eukaryota.
DR   HOGENOM; CLU_473651_0_0_1; -.
DR   InParanoid; Q54XE8; -.
DR   OMA; FFQKGYR; -.
DR   PhylomeDB; Q54XE8; -.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-9013148; CDC42 GTPase cycle.
DR   Reactome; R-DDI-9013149; RAC1 GTPase cycle.
DR   Reactome; R-DDI-9013423; RAC3 GTPase cycle.
DR   Reactome; R-DDI-9013424; RHOV GTPase cycle.
DR   PRO; PR:Q54XE8; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0043087; P:regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF103657; SSF103657; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; GTPase activation; Reference proteome.
FT   CHAIN           1..576
FT                   /note="Rho GTPase-activating protein gacP"
FT                   /id="PRO_0000380214"
FT   DOMAIN          277..462
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   REGION          472..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          123..189
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        474..534
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   576 AA;  65649 MW;  4A0D28A203F8DC62 CRC64;
     MKNFKAKIIT AKQNVMEKTA KRENTLEPDE MKELEKKTTE TKDFLRKLTK SVEKETLSSG
     VSIQDGTELA DNFLDYSVHV RDNQSDLVIL SGILSKIGEF QAGFEDLKSK LNSSLINDVS
     DPLKSIIKTE LKQAKESKRE YDRVRVAFDA HLSELANLRK QKNVKPPKIQ ESEEECERLR
     TNFERVGIDT TCLLRDTNVI TEFETVEKLC DYLDSYHTFF QKGYRWLAQM IPDIYEYRLY
     VEKRKAELEK SKVRISMMVS PQKQQADSLS KTKCFGEDLS VLLNREGSTL PWFIVRAFQA
     IRNHIATEEG LFRLSGTKRI IYEYKQKIDE GKEYNLSEIL DIHVVCNLVK LYLRELQPEP
     LLTYSRYNEL IDTCNIEDQN QRVDKISKIL SSLPKHYYTL LHHLIHLLSQ IASQPKSKMG
     PANLATVIGP NILICQTDVV LEDIALGNMV VTTIIQNFDR IFGGPPLLQQ SVPDTYVPPP
     NNTRNNSVNN FNNVQPSSFS ASTSRSINLN KSTNNPNIND DNNNNNNINN SDDEPYDPNA
     PPIYSGVPMR GNIKHSDSCS TLGDSFDEGD AVELSD