GACR_DICDI
ID GACR_DICDI Reviewed; 783 AA.
AC Q54XT6;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Rho GTPase-activating protein gacR;
DE AltName: Full=GTPase activating factor for raC protein R;
GN Name=gacR; ORFNames=DDB_G0278755;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC transduction pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AAFI02000024; EAL67979.1; -; Genomic_DNA.
DR RefSeq; XP_641917.1; XM_636825.1.
DR AlphaFoldDB; Q54XT6; -.
DR SMR; Q54XT6; -.
DR STRING; 44689.DDB0233843; -.
DR PaxDb; Q54XT6; -.
DR EnsemblProtists; EAL67979; EAL67979; DDB_G0278755.
DR GeneID; 8621676; -.
DR KEGG; ddi:DDB_G0278755; -.
DR dictyBase; DDB_G0278755; gacR.
DR eggNOG; KOG4406; Eukaryota.
DR HOGENOM; CLU_358064_0_0_1; -.
DR InParanoid; Q54XT6; -.
DR OMA; RPQSVMF; -.
DR PhylomeDB; Q54XT6; -.
DR Reactome; R-DDI-9013148; CDC42 GTPase cycle.
DR Reactome; R-DDI-9013149; RAC1 GTPase cycle.
DR Reactome; R-DDI-9013404; RAC2 GTPase cycle.
DR Reactome; R-DDI-9013406; RHOQ GTPase cycle.
DR Reactome; R-DDI-9013409; RHOJ GTPase cycle.
DR Reactome; R-DDI-9013423; RAC3 GTPase cycle.
DR PRO; PR:Q54XT6; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IBA:GO_Central.
DR Gene3D; 1.10.555.10; -; 1.
DR Gene3D; 1.20.1270.60; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; GTPase activation; Reference proteome.
FT CHAIN 1..783
FT /note="Rho GTPase-activating protein gacR"
FT /id="PRO_0000380216"
FT DOMAIN 319..509
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 262..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 138..188
FT /evidence="ECO:0000255"
FT COMPBIAS 272..289
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 783 AA; 86060 MW; 57AD5D7F7B84F781 CRC64;
MKKFNQTFSS VKDLIGNKKE TLTEFPDYIY KTKSLEDLKG YTRTLNLKLT KHSKTNQLLI
EENKQLSEQI LLYSNLFINN EESSLNVCEP LSNVFKIVGE MINEIENYRQ TFEQSISQKW
LQQLNEYGKS DCKDGQLAKN RFDKARLSFD EASEQFKQLR KKQNNINNEK LLEAEEDLDY
ATQQFSDIAS ESLQTMDDII VKHNLDSFES ASSTIQSYKD FFQKGLDHCL SVQSDLEIQK
HAMSKYKQQL LEKKKLRSTV VQFEQTNSSR TISLPPPPPP KPTSSTPSSS PSPSPSSSII
NIHNNYIAMP KGNTKVFGMA LSTITEREKS DIPMIIDKSI QFLLLEENIT QEGIFRVSPN
QKQLTDLKNN VNAGYITTLD GIDDAHLISS FVKAFLREMP IPLFTFDLYH SLVDCVINEE
KYDCDKIKIS NAIVLVLQKL PKPNFLLAKS LISLLWKIST KSSQNKMTTS NLAVTVAPNV
LYPKLLDIRS LTNANATIEF IISNFNNIFN NQLISNLYNN SCGVSGGSSG GGGGGGSSGG
VANPRHSVLP PSLPARPQSV MFKNTPLSVN TSSSQSSSSS SSSSFASSAS PPPTPTKPPS
SSSSPIITTT SPNSNTNINS NTSVNTNINP RHSVLPPSLP PKKISSSSNS LPSPPPPSSP
SIPEKSQNNI TPTILSSSLS APTSPTTTTT TNPLRSSTGS PKPISNRVSM YLQNSNTGVP
LPSQKPQRVI SNNNTTTNSR PLSNSLDLPP PLAPVGMPLE TLEPIQRNLT SNEAITISEV
NWN
