GACX_DICDI
ID GACX_DICDI Reviewed; 563 AA.
AC Q54J98;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Rho GTPase-activating protein gacX;
DE AltName: Full=GTPase activating factor for raC protein X;
GN Name=gacX; ORFNames=DDB_G0288205;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC transduction pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AAFI02000109; EAL63333.1; -; Genomic_DNA.
DR RefSeq; XP_636838.1; XM_631746.1.
DR AlphaFoldDB; Q54J98; -.
DR SMR; Q54J98; -.
DR STRING; 44689.DDB0233795; -.
DR PaxDb; Q54J98; -.
DR EnsemblProtists; EAL63333; EAL63333; DDB_G0288205.
DR GeneID; 8626507; -.
DR KEGG; ddi:DDB_G0288205; -.
DR dictyBase; DDB_G0288205; gacX.
DR eggNOG; KOG4270; Eukaryota.
DR HOGENOM; CLU_484346_0_0_1; -.
DR InParanoid; Q54J98; -.
DR OMA; DMMELMA; -.
DR PhylomeDB; Q54J98; -.
DR Reactome; R-DDI-9013148; CDC42 GTPase cycle.
DR Reactome; R-DDI-9013149; RAC1 GTPase cycle.
DR Reactome; R-DDI-9013404; RAC2 GTPase cycle.
DR Reactome; R-DDI-9013406; RHOQ GTPase cycle.
DR Reactome; R-DDI-9013409; RHOJ GTPase cycle.
DR Reactome; R-DDI-9013423; RAC3 GTPase cycle.
DR PRO; PR:Q54J98; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IBA:GO_Central.
DR Gene3D; 1.10.555.10; -; 1.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48350; SSF48350; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; GTPase activation; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..563
FT /note="Rho GTPase-activating protein gacX"
FT /id="PRO_0000380221"
FT DOMAIN 51..238
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REPEAT 260..301
FT /note="WD 1"
FT REPEAT 303..340
FT /note="WD 2"
FT REPEAT 383..422
FT /note="WD 3"
FT REPEAT 470..509
FT /note="WD 4"
FT REPEAT 514..556
FT /note="WD 5"
SQ SEQUENCE 563 AA; 63054 MW; 1949C6CE119F198F CRC64;
MSNNNNRASI YGGLGSVGKI FGAPLLDVVM NQKSKTTSLN SSSSATNNNN STVEEVNIPL
FLHNGFKYII QHGLGIEGIF RIAGTKDKVK QLQMQLDKGE NIDYDASKVD PVDLADLMKI
YFRELPDCLL QSDQYDHFIS LLTLDRLGQI QKLRELVSSL RPENREMLKQ LIWFLGRIAV
NSTTNKMSEE NLGLVWGPNL LWKGGKAVST TDMMELMAGA GKIKLIVTLL IEEQEHVFNN
LNATITKGEM KVSFINKIVG NKKTCQGISI IEDGESKSIW TADSAGIIKV FNADNYVTER
EWDSNLGRIH TMTSVRDHAW IASSQSVSLW NKAGNLVKEF PGFHVSLTPV YSHGEYRIWA
GTDQKITIFS SNTLEIVQTI SIPGQFIVSI TEIFGESNQV WVGATGGQII IFDKTTGEEI
RKLSTPAKRN ITCLTFHKYM DKGKVWAGSE DKLIFVIDPF DDYSIVQTVS HPDLLLINTL
KSISKSVWSC SRDSSIRIWD SNSFELLGSL DDYHTDAVID AILTYNNRKM RWEFWTASFD
KSVCIWSVSS ELLSQPPPPL LNV
