GACY_DICDI
ID GACY_DICDI Reviewed; 721 AA.
AC Q54TH9;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Rho GTPase-activating protein gacY;
DE AltName: Full=GTPase activating factor for raC protein Y;
GN Name=gacY; ORFNames=DDB_G0281739;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC transduction pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000042; EAL66631.1; -; Genomic_DNA.
DR RefSeq; XP_640612.1; XM_635520.1.
DR AlphaFoldDB; Q54TH9; -.
DR SMR; Q54TH9; -.
DR STRING; 44689.DDB0233758; -.
DR PaxDb; Q54TH9; -.
DR EnsemblProtists; EAL66631; EAL66631; DDB_G0281739.
DR GeneID; 8623222; -.
DR KEGG; ddi:DDB_G0281739; -.
DR dictyBase; DDB_G0281739; gacY.
DR eggNOG; KOG4406; Eukaryota.
DR HOGENOM; CLU_383784_0_0_1; -.
DR InParanoid; Q54TH9; -.
DR OMA; PQYHTID; -.
DR PhylomeDB; Q54TH9; -.
DR Reactome; R-DDI-9013148; CDC42 GTPase cycle.
DR Reactome; R-DDI-9013149; RAC1 GTPase cycle.
DR Reactome; R-DDI-9013404; RAC2 GTPase cycle.
DR Reactome; R-DDI-9013406; RHOQ GTPase cycle.
DR Reactome; R-DDI-9013409; RHOJ GTPase cycle.
DR Reactome; R-DDI-9013423; RAC3 GTPase cycle.
DR PRO; PR:Q54TH9; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IBA:GO_Central.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 1.10.555.10; -; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasm; GTPase activation; Reference proteome.
FT CHAIN 1..721
FT /note="Rho GTPase-activating protein gacY"
FT /id="PRO_0000380222"
FT DOMAIN 363..520
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT DOMAIN 528..719
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 1..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..182
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 721 AA; 80873 MW; 652C3E13221E0D4E CRC64;
MDSSFKRASF KLPPGVNIDN INEMNNNNMN TAPAPAPAPI PTPQPTTTTT TAPQRKVTFG
SRVRAQEINA TPTPTTPAPA PTTTPSENDT AKKDDFDFDP VPVSRPRATR AATMIPSNML
GDKRPIRPLG KGFIGADRQT PKPETDNNNN GNNNNNNNNN DNNNNNNNND DDDEDEDDDE
YSNVSAPSWN SVLSKAKTNT MNSRKRSGMI HDFVDVNIKN DSGGENSANT TSEDGSSSRR
GTLRKAIVIG THNPQPQQED DVEETTSRIS SLDLANVQRP RPQYHTIDPA SIPQWKKNNE
DLVNTMEQQQ QQPQQPQQPQ QQQSTVGGLF NSILKKQPNN NANNAQRLTR AEAEYNEYLT
KSKSQRFPEI EALNFIYPAG KDNLGRTIIV IIASHLPVRE MDMERVLLYT ISIMDPVVEE
EYVLVYVHTN MNNSNKPSMA WMKKVYTIFN RKYKKNLKGL YIVHPTTWIK FTLGIFKHFL
SSKFWKKLTY IDDLGELFKT FPREQLALPN AIMMHRPAGK KSQPIFGAPL EDVINRPDNP
GEIPVLFEKG IAYLSRRGLQ VEGLFRLSGA NSQIKSLRQG FDQGEDVDLE DVEDVHTVAG
LLKLYLRELP SPLFPFDLYS SFIEISKGEQ TKPQKVESLK LLLSLLPPAN KALSKHLFKF
LGKVIENSSV NKMNSVNLSI VFAPNLLKDK EGNVMDAVAD AQFVNQVVQL ILDNINILFN
Y
