GAD1_DROME
ID GAD1_DROME Reviewed; 655 AA.
AC Q9W1J3;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Gastrulation defective protein 1 homolog;
GN ORFNames=CG5543;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SIMILARITY: Belongs to the WD repeat GAD-1 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF47065.1; -; Genomic_DNA.
DR EMBL; AY058624; AAL13853.1; -; mRNA.
DR EMBL; AY113366; AAM29371.1; -; mRNA.
DR RefSeq; NP_611832.1; NM_137988.3.
DR AlphaFoldDB; Q9W1J3; -.
DR SMR; Q9W1J3; -.
DR IntAct; Q9W1J3; 2.
DR STRING; 7227.FBpp0072033; -.
DR PaxDb; Q9W1J3; -.
DR PRIDE; Q9W1J3; -.
DR DNASU; 37768; -.
DR EnsemblMetazoa; FBtr0072124; FBpp0072033; FBgn0034908.
DR GeneID; 37768; -.
DR KEGG; dme:Dmel_CG5543; -.
DR UCSC; CG5543-RA; d. melanogaster.
DR FlyBase; FBgn0034908; CG5543.
DR VEuPathDB; VectorBase:FBgn0034908; -.
DR eggNOG; KOG0772; Eukaryota.
DR GeneTree; ENSGT00390000015433; -.
DR HOGENOM; CLU_014033_1_2_1; -.
DR InParanoid; Q9W1J3; -.
DR OMA; QGGLRTN; -.
DR OrthoDB; 729650at2759; -.
DR PhylomeDB; Q9W1J3; -.
DR BioGRID-ORCS; 37768; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37768; -.
DR PRO; PR:Q9W1J3; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034908; Expressed in egg cell and 20 other tissues.
DR Genevisible; Q9W1J3; DM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR GO; GO:1903775; P:regulation of DNA double-strand break processing; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..655
FT /note="Gastrulation defective protein 1 homolog"
FT /id="PRO_0000305142"
FT REPEAT 180..219
FT /note="WD 1"
FT REPEAT 227..268
FT /note="WD 2"
FT REPEAT 281..321
FT /note="WD 3"
FT REPEAT 330..369
FT /note="WD 4"
FT REPEAT 377..416
FT /note="WD 5"
FT REPEAT 422..467
FT /note="WD 6"
FT REPEAT 470..510
FT /note="WD 7"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..160
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..655
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 655 AA; 73608 MW; 4A3EF0602E253FEC CRC64;
MQRGKISFGK IKLNVNVPPA EPRSNETEAE DAKESTEASG NGGGFKKMDK EQMIRQIEDV
AEDLESQHLK EVMGISGFGR KAAKVFDINE QIEKARVTRP GMDKKREESK PKEDDQKDEE
EEDVIGPLPP AVTTDKEKAT KESSKDEDSD DDDYSSDEDS DDEQSLAKRI PYTHEVQMQH
GSRAVLALAG DPSGARLVSG SIDYDMCFWD FAGMDSSMRS FRQLQPCENH PIRSLQYSVT
GDMILVISGN AQAKVLDRDG FEKLECCKGD QYISDMSRTK GHVAQLTSGC WHPFNREQFL
TAALDGTLRI WQGLKSKEQL QVIKTRAQGG LRTNAASCNF NRDATLIAAG CVDGSIQTWD
TRKMFVNTTH CVRDAHQKGS EITSIVFSYM GQQLATRSND ETMKLWDLRQ FKQPLHTWTN
LFSRYDTTDC CFSPDDRLLV TGESLPKGQA EANLYFYSTK SYEEVQRIPV SNAHVVKTLW
HPKLNQLFVS CGNGTIKCYY DEHRSIRGAK LCVVKTHRKR QPMEMVGVSQ IITPHALPLF
RQEKSRTSRK RMEKARMDPV KSQRPDLPIT SGQGGRVASS GGTLSSYVIR NLGLSKRVDD
DQDPREAILK YAKDAAENPY WIAPAYKQTQ PKAIFSEKLP ADEPATKKPK TEADK
