ID   GADE_ECOL6              Reviewed;         175 AA.
AC   P63205; P29688;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2004, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Transcriptional regulator GadE;
GN   Name=gadE; OrderedLocusNames=c4323;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Regulates the expression of several genes involved in acid
CC       resistance. Required for the expression of gadA and gadBC, among
CC       others, regardless of media or growth conditions. Binds directly to the
CC       20 bp GAD box found in the control regions of both loci (By
CC       similarity). {ECO:0000250}.
CC   -!- INDUCTION: By acidic conditions. Could be induced by EvgA via the
CC       induction of YdeO (By similarity). {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN82759.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN82759.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000576690.1; NC_004431.1.
DR   AlphaFoldDB; P63205; -.
DR   SMR; P63205; -.
DR   STRING; 199310.c4323; -.
DR   EnsemblBacteria; AAN82759; AAN82759; c4323.
DR   GeneID; 66672604; -.
DR   KEGG; ecc:c4323; -.
DR   eggNOG; COG2771; Bacteria.
DR   HOGENOM; CLU_1522892_0_0_6; -.
DR   OMA; INNISDM; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..175
FT                   /note="Transcriptional regulator GadE"
FT                   /id="PRO_0000184156"
FT   DOMAIN          109..174
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        133..152
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   175 AA;  20599 MW;  5CCC69A0DA53B293 CRC64;
     MIFLMTKDSF LLQGFWQLKD NHEMIKINSL SEIKKVGNKP FKVIIDTYHN HILDEEAIKF
     LEKLDAERII VLAPYHISKL KAKAPIYFVS RKESIKNLLE ITYGKHLPHK NSQLCFSHNQ
     FKIMQLILKN KNESNITSTL NISQQTLKIQ KFNIMYKLKL RRMSDIVTLG ITSYF