ID   GADR3_CAEEL             Reviewed;         710 AA.
AC   Q09562;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Gastrulation-defective protein 3;
GN   Name=gadr-3; ORFNames=F47D12.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; FO080618; CCD83375.1; -; Genomic_DNA.
DR   PIR; F88478; F88478.
DR   RefSeq; NP_498378.2; NM_065977.2.
DR   AlphaFoldDB; Q09562; -.
DR   SMR; Q09562; -.
DR   BioGRID; 50688; 1.
DR   DIP; DIP-27183N; -.
DR   STRING; 6239.F47D12.5; -.
DR   EPD; Q09562; -.
DR   PaxDb; Q09562; -.
DR   EnsemblMetazoa; F47D12.5.1; F47D12.5.1; WBGene00018561.
DR   GeneID; 185933; -.
DR   KEGG; cel:CELE_F47D12.5; -.
DR   UCSC; F47D12.5; c. elegans.
DR   CTD; 185933; -.
DR   WormBase; F47D12.5; CE43720; WBGene00018561; gadr-3.
DR   eggNOG; KOG3665; Eukaryota.
DR   GeneTree; ENSGT00530000065009; -.
DR   HOGENOM; CLU_022099_0_0_1; -.
DR   InParanoid; Q09562; -.
DR   OMA; AAINCHI; -.
DR   OrthoDB; 1333044at2759; -.
DR   PhylomeDB; Q09562; -.
DR   PRO; PR:Q09562; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00018561; Expressed in embryo and 3 other tissues.
DR   GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   4: Predicted;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..710
FT                   /note="Gastrulation-defective protein 3"
FT                   /id="PRO_0000065352"
FT   TRANSMEM        597..615
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   710 AA;  81889 MW;  C567094414C17BD8 CRC64;
     MINALSCIAT EKVAHYINDG IYRNLKYKLD SKSSDQVYSK LLKISRGLIH EYNHEIGQRL
     ELRNVDYGKF KIDRNTVMVL KKHCLESLGI GDLDYIGYYY RDLIDDNTID IFELLKAILN
     NETRRNLHYL DIKGSHAFSK KWTKNIGTIL PVLRSLIICG RHLQSDDFQQ LCESIPNLTY
     LDISETNVPN ISGISSLKNL ESLIMRSVEL ECFEQFVDLF NLTGLRILDV SRSMYKHDTK
     IINQYVQSNK VLKELRFLEC SGTDINKNLL EQILNSHDNL QQVAAINCHI RSLSLHHEVF
     LLNTATLTSS LKSLTHYLGV HRISSVERVL ENMLHLFPKY DPDLDNRFDF SECVKIIINS
     ALKIESSLGI QGYGTLCLWH IARNQDARFQ PFDLYQLVCK LLDGVYNNGR LFIATKDFNI
     SLWRTIESLL KLLESSLKPM SYERVCRIAG LCISRNEVDD EMKTRAIPIF ATYIKRISSQ
     SVYYIDFNHK LMPKIILHLK KSIELRKTYW ITFCLDILTQ ITQNSADACE KLAECEEMNV
     LLECFGNLTK ASDHLKILKI LKNVLLELTD KNVKHVAIDA RISVLQERLD EWDDERAYYV
     FTVLALIISN FPTIVNREPA NSLIRECFPE ISNVIKIPVS DSKIYVKNGI LKKILKDSRE
     DGSLLWALLV IKSSMEQDKS FVNLLTTEMS NLNTNSEIIM NMKAEIKNLI