ID   GADX_ECOL6              Reviewed;         274 AA.
AC   Q8FCI6;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=HTH-type transcriptional regulator GadX;
GN   Name=gadX; OrderedLocusNames=c4327;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Positively regulates the expression of about fifteen genes
CC       involved in acid resistance such as gadA, gadB and gadC. Depending on
CC       the conditions (growth phase and medium), can repress gadW (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- INDUCTION: Expression can be activated by RpoS and repressed by CRP, H-
CC       NS and GadW, depending on the conditions. {ECO:0000250}.
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DR   EMBL; AE014075; AAN82763.1; -; Genomic_DNA.
DR   RefSeq; WP_001182743.1; NC_004431.1.
DR   AlphaFoldDB; Q8FCI6; -.
DR   SMR; Q8FCI6; -.
DR   STRING; 199310.c4327; -.
DR   EnsemblBacteria; AAN82763; AAN82763; c4327.
DR   KEGG; ecc:c4327; -.
DR   eggNOG; COG2207; Bacteria.
DR   HOGENOM; CLU_091292_0_0_6; -.
DR   OMA; NIANDWS; -.
DR   BioCyc; ECOL199310:C4327-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..274
FT                   /note="HTH-type transcriptional regulator GadX"
FT                   /id="PRO_0000194521"
FT   DOMAIN          145..242
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        162..183
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        209..232
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   274 AA;  31306 MW;  0944880015520A64 CRC64;
     MQPLHGNCLI AYARHKYILT MVNGEYRYFN GGDLVFADAS QIQVDKCVEN FVLVSRDTLS
     LFLPMLKEEA LKLHVHKKVP SLLVHHCTRD IPVFQEVAQL SQNKNLRYAE MLRKRALIFA
     LLSVFLEDTQ FIPLLLNVLQ PNMRTRVCTV INNNIAHEWT LARIASELLM SPSLLKKKLR
     EEGTSYSQLL TECRMQRALQ LIVIYGVSIK RVAVSCGYHS VSYFIYVFRN YYGMTPTEYQ
     ERSAQELPNC GSAASMAAQG IFYGTDRSAE GIRL