ID   GAFA_DICDI              Reviewed;         158 AA.
AC   Q8MTJ7; Q55BH5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=GAF domain-containing protein A;
GN   Name=gafA; ORFNames=DDB_G0271136;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=12011437; DOI=10.1073/pnas.102167299;
RA   Goldberg J.M., Bosgraaf L., Van Haastert P.J.M., Smith J.L.;
RT   "Identification of four candidate cGMP targets in Dictyostelium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:6749-6754(2002).
CC   -!- SIMILARITY: Belongs to the free Met sulfoxide reductase family.
CC       {ECO:0000305}.
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DR   EMBL; AY099028; AAM44404.1; -; Genomic_DNA.
DR   EMBL; AAFI02000006; EAL71698.1; -; Genomic_DNA.
DR   RefSeq; XP_645637.1; XM_640545.1.
DR   AlphaFoldDB; Q8MTJ7; -.
DR   SMR; Q8MTJ7; -.
DR   STRING; 44689.DDB0215340; -.
DR   PaxDb; Q8MTJ7; -.
DR   EnsemblProtists; EAL71698; EAL71698; DDB_G0271136.
DR   GeneID; 8617829; -.
DR   KEGG; ddi:DDB_G0271136; -.
DR   dictyBase; DDB_G0271136; gafA.
DR   eggNOG; ENOG502RXXR; Eukaryota.
DR   HOGENOM; CLU_077738_2_0_1; -.
DR   InParanoid; Q8MTJ7; -.
DR   OMA; DNYIACS; -.
DR   PhylomeDB; Q8MTJ7; -.
DR   PRO; PR:Q8MTJ7; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0070191; F:methionine-R-sulfoxide reductase activity; IBA:GO_Central.
DR   Gene3D; 3.30.450.40; -; 1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   Pfam; PF13185; GAF_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..158
FT                   /note="GAF domain-containing protein A"
FT                   /id="PRO_0000328249"
FT   DOMAIN          32..158
FT                   /note="GAF"
SQ   SEQUENCE   158 AA;  17663 MW;  A95DC6658C49FC22 CRC64;
     MAEDLEISKG SKEEQYENLL PQIEGLLTGE NNQIANLANV TAALKEQFNF FWVGFYLVDT
     ENELVLAPFQ GPIACTRIRK GRGVCGTAWQ QEKTLIVPDV EKFPGHIACS SLSKSEIVLP
     LYKQGNIIGV LDVDSDKLNS FDEIDEKYLT QILKLLDN