ID   GAG10_HUMAN             Reviewed;         116 AA.
AC   A6NGK3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=G antigen 10;
DE            Short=GAGE-10;
GN   Name=GAGE10;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2]
RP   GAGE FAMILY.
RX   PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA   Gjerstorff M.F., Ditzel H.J.;
RT   "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT   newly identified members.";
RL   Tissue Antigens 71:187-192(2008).
CC   -!- INTERACTION:
CC       A6NGK3; Q96IK5: GMCL1; NbExp=4; IntAct=EBI-12281306, EBI-2548508;
CC   -!- MISCELLANEOUS: This gene belongs to a multigene family expressed in a
CC       large variety of tumors whereas in normal tissues, expression is
CC       restricted to germ cells. These genes organized in clustered repeats,
CC       have a high degree of predicted sequence identity, but differ by
CC       scattered single nucleotide substitution. Their sequences contain
CC       either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized
CC       by cytotoxic T-cells.
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC   -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC       sequences, but the high identity of the GAGE members made impossible to
CC       separate products of paralogous genes from polymorph products.
CC       PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC       identified genes and their products. {ECO:0000305}.
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DR   EMBL; AF235097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS78483.1; -.
DR   AlphaFoldDB; A6NGK3; -.
DR   IntAct; A6NGK3; 1.
DR   STRING; 9606.ENSP00000385415; -.
DR   iPTMnet; A6NGK3; -.
DR   PhosphoSitePlus; A6NGK3; -.
DR   BioMuta; GAGE10; -.
DR   jPOST; A6NGK3; -.
DR   MassIVE; A6NGK3; -.
DR   MaxQB; A6NGK3; -.
DR   PaxDb; A6NGK3; -.
DR   PeptideAtlas; A6NGK3; -.
DR   PRIDE; A6NGK3; -.
DR   DNASU; 643832; -.
DR   Ensembl; ENST00000407599.4; ENSP00000385415.3; ENSG00000215274.6.
DR   MANE-Select; ENST00000407599.4; ENSP00000385415.3; NM_001098413.4; NP_001091883.3.
DR   UCSC; uc033ede.2; human.
DR   GeneCards; GAGE10; -.
DR   HGNC; HGNC:30968; GAGE10.
DR   HPA; ENSG00000215274; Tissue enhanced (brain, testis).
DR   MIM; 300737; gene.
DR   neXtProt; NX_A6NGK3; -.
DR   OpenTargets; ENSG00000215274; -.
DR   PharmGKB; PA145148765; -.
DR   VEuPathDB; HostDB:ENSG00000215274; -.
DR   eggNOG; ENOG502SZ68; Eukaryota.
DR   GeneTree; ENSGT00940000153097; -.
DR   HOGENOM; CLU_150116_0_0_1; -.
DR   InParanoid; A6NGK3; -.
DR   PhylomeDB; A6NGK3; -.
DR   TreeFam; TF340669; -.
DR   PathwayCommons; A6NGK3; -.
DR   SignaLink; A6NGK3; -.
DR   Pharos; A6NGK3; Tdark.
DR   PRO; PR:A6NGK3; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; A6NGK3; protein.
DR   Bgee; ENSG00000215274; Expressed in pituitary gland and 81 other tissues.
DR   Genevisible; A6NGK3; HS.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047; PTHR14047; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..116
FT                   /note="G antigen 10"
FT                   /id="PRO_0000337202"
FT   REGION          1..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         11
FT                   /note="P -> S (in dbSNP:rs782631403)"
FT                   /id="VAR_085737"
FT   VARIANT         15
FT                   /note="R -> L (in dbSNP:rs782469432)"
FT                   /id="VAR_085738"
SQ   SEQUENCE   116 AA;  12704 MW;  282FABAE1BD3D6D5 CRC64;
     MSWRGRSTYR PRPRRYVEPP EMIGPMLPEQ FSDEVEPATP EEGEPATQRQ DPAAAQEGED
     EGASAGQGPK PEADSQEQVH PKTGCECGDG PDGQEMGLPN PEEVKRPEEG EKQSQC