ID   GAG13_HUMAN             Reviewed;         117 AA.
AC   Q4V321; A0A087X111;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 2.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=G antigen 13 {ECO:0000305};
DE            Short=GAGE-13;
DE   AltName: Full=G antigen 12A;
DE            Short=GAGE-12A;
GN   Name=GAGE13 {ECO:0000312|HGNC:HGNC:29081}; Synonyms=GAGE12A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2]
RP   GAGE FAMILY.
RX   PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA   Gjerstorff M.F., Ditzel H.J.;
RT   "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT   newly identified members.";
RL   Tissue Antigens 71:187-192(2008).
CC   -!- MISCELLANEOUS: This gene belongs to a multigene family expressed in a
CC       large variety of tumors whereas in normal tissues, expression is
CC       restricted to germ cells. These genes organized in clustered repeats,
CC       have a high degree of predicted sequence identity, but differ by
CC       scattered single nucleotide substitution. Their sequences contain
CC       either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized
CC       by cytotoxic T-cells.
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC   -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC       sequences, but the high identity of the GAGE members made impossible to
CC       separate products of paralogous genes from polymorph products.
CC       PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC       identified genes and their products. {ECO:0000305}.
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DR   EMBL; AC233302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX649339; CAI95426.1; -; Genomic_DNA.
DR   EMBL; AF235097; CAI95426.1; JOINED; Genomic_DNA.
DR   CCDS; CCDS48110.1; -.
DR   RefSeq; NP_001091882.2; NM_001098412.2.
DR   AlphaFoldDB; Q4V321; -.
DR   STRING; 9606.ENSP00000483811; -.
DR   BioMuta; GAGE13; -.
DR   DMDM; 74753563; -.
DR   jPOST; Q4V321; -.
DR   MassIVE; Q4V321; -.
DR   PaxDb; Q4V321; -.
DR   PeptideAtlas; Q4V321; -.
DR   PRIDE; Q4V321; -.
DR   Antibodypedia; 72467; 32 antibodies from 6 providers.
DR   DNASU; 645051; -.
DR   Ensembl; ENST00000612958.2; ENSP00000483811.1; ENSG00000274274.2.
DR   GeneID; 645051; -.
DR   KEGG; hsa:645051; -.
DR   MANE-Select; ENST00000612958.2; ENSP00000483811.1; NM_001098412.4; NP_001091882.2.
DR   CTD; 645051; -.
DR   GeneCards; GAGE13; -.
DR   HGNC; HGNC:29081; GAGE13.
DR   HPA; ENSG00000274274; Tissue enriched (testis).
DR   MIM; 300734; gene.
DR   neXtProt; NX_Q4V321; -.
DR   OpenTargets; ENSG00000274274; -.
DR   VEuPathDB; HostDB:ENSG00000274274; -.
DR   GeneTree; ENSGT00940000153097; -.
DR   InParanoid; Q4V321; -.
DR   OrthoDB; 1575904at2759; -.
DR   PhylomeDB; Q4V321; -.
DR   TreeFam; TF340669; -.
DR   PathwayCommons; Q4V321; -.
DR   BioGRID-ORCS; 645051; 2 hits in 64 CRISPR screens.
DR   ChiTaRS; GAGE13; human.
DR   GenomeRNAi; 645051; -.
DR   Pharos; Q4V321; Tdark.
DR   PRO; PR:Q4V321; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q4V321; protein.
DR   Bgee; ENSG00000274274; Expressed in right testis and 68 other tissues.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047; PTHR14047; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..117
FT                   /note="G antigen 13"
FT                   /id="PRO_0000252476"
FT   REGION          1..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..117
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        11
FT                   /note="W -> R (in Ref. 1; CAI95426)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        50
FT                   /note="R -> C (in Ref. 1; CAI95426)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        112
FT                   /note="E -> K (in Ref. 1; CAI95426)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   117 AA;  12957 MW;  375ACB1AF3800671 CRC64;
     MSWRGRSTYY WPRPRRYVEP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE
     DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC