ID   GAG2A_HUMAN             Reviewed;         116 AA.
AC   Q6NT46;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=G antigen 2A;
DE            Short=GAGE-2A;
GN   Name=GAGE2A; Synonyms=GAGE2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   CHARACTERIZATION OF ANTIGENIC PEPTIDES.
RX   PubMed=10397259;
RA   De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S.,
RA   Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T.,
RA   van der Bruggen P.;
RT   "Characterization of the GAGE genes that are expressed in various human
RT   cancers and in normal testis.";
RL   Cancer Res. 59:3157-3165(1999).
RN   [4]
RP   GAGE FAMILY.
RX   PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA   Gjerstorff M.F., Ditzel H.J.;
RT   "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT   newly identified members.";
RL   Tissue Antigens 71:187-192(2008).
CC   -!- MISCELLANEOUS: This gene belongs to a multigene family expressed in a
CC       large variety of tumors whereas in normal tissues, expression is
CC       restricted to germ cells. These genes organized in clustered repeats,
CC       have a high degree of predicted sequence identity, but differ by
CC       scattered single nucleotide substitution. Their sequences contain
CC       either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized
CC       by cytotoxic T-cells.
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC   -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC       sequences, but the high identity of the GAGE members made impossible to
CC       separate products of paralogous genes from polymorph products.
CC       PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC       identified genes and their products. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC142497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC069397; AAH69397.1; -; mRNA.
DR   CCDS; CCDS48114.1; -.
DR   RefSeq; NP_001120684.1; NM_001127212.1.
DR   AlphaFoldDB; Q6NT46; -.
DR   BioGRID; 609848; 2.
DR   STRING; 9606.ENSP00000355421; -.
DR   iPTMnet; Q6NT46; -.
DR   PhosphoSitePlus; Q6NT46; -.
DR   BioMuta; GAGE2A; -.
DR   DMDM; 74736753; -.
DR   jPOST; Q6NT46; -.
DR   MassIVE; Q6NT46; -.
DR   MaxQB; Q6NT46; -.
DR   PaxDb; Q6NT46; -.
DR   PeptideAtlas; Q6NT46; -.
DR   PRIDE; Q6NT46; -.
DR   ProteomicsDB; 66657; -.
DR   TopDownProteomics; Q6NT46; -.
DR   Antibodypedia; 57024; 52 antibodies from 8 providers.
DR   DNASU; 729447; -.
DR   Ensembl; ENST00000362097.2; ENSP00000355421.1; ENSG00000189064.9.
DR   GeneID; 729447; -.
DR   KEGG; hsa:729447; -.
DR   MANE-Select; ENST00000362097.2; ENSP00000355421.1; NM_001127212.4; NP_001120684.1.
DR   UCSC; uc004doi.6; human.
DR   CTD; 729447; -.
DR   DisGeNET; 729447; -.
DR   GeneCards; GAGE2A; -.
DR   HGNC; HGNC:4099; GAGE2A.
DR   HPA; ENSG00000189064; Tissue enriched (testis).
DR   MIM; 300720; gene.
DR   neXtProt; NX_Q6NT46; -.
DR   OpenTargets; ENSG00000189064; -.
DR   PharmGKB; PA162389230; -.
DR   VEuPathDB; HostDB:ENSG00000189064; -.
DR   eggNOG; ENOG502SZ68; Eukaryota.
DR   GeneTree; ENSGT00940000153097; -.
DR   HOGENOM; CLU_150116_0_0_1; -.
DR   InParanoid; Q6NT46; -.
DR   OMA; NHANCRV; -.
DR   OrthoDB; 1575904at2759; -.
DR   PhylomeDB; Q6NT46; -.
DR   TreeFam; TF340669; -.
DR   PathwayCommons; Q6NT46; -.
DR   BioGRID-ORCS; 729447; 15 hits in 216 CRISPR screens.
DR   ChiTaRS; GAGE2A; human.
DR   GenomeRNAi; 729447; -.
DR   Pharos; Q6NT46; Tdark.
DR   PRO; PR:Q6NT46; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q6NT46; protein.
DR   Bgee; ENSG00000189064; Expressed in right testis and 69 other tissues.
DR   Genevisible; Q6NT46; HS.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047; PTHR14047; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..116
FT                   /note="G antigen 2A"
FT                   /id="PRO_0000395445"
FT   REGION          1..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   116 AA;  12785 MW;  DD24495CB68EF19A CRC64;
     MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ DPAAAQEGQD
     EGASAGQGPK PEAHSQEQGH PQTGCECEDG PDGQEMDPPN PEEVKTPEEG EKQSQC