GAG2B_HUMAN
ID GAG2B_HUMAN Reviewed; 116 AA.
AC Q13066; C9K0W9; Q4V322;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 150.
DE RecName: Full=G antigen 2B/2C;
DE Short=GAGE-2B;
DE Short=GAGE-2C;
DE AltName: Full=Cancer/testis antigen 4.2;
DE Short=CT4.2;
DE AltName: Full=G antigen 2C;
GN Name=GAGE2B; Synonyms=GAGE2;
GN and
GN Name=GAGE2C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Melanoma;
RX PubMed=7544395; DOI=10.1084/jem.182.3.689;
RA van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.;
RT "A new family of genes coding for an antigen recognized by autologous
RT cytolytic T lymphocytes on a human melanoma.";
RL J. Exp. Med. 182:689-698(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP GAGE FAMILY.
RX PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA Gjerstorff M.F., Ditzel H.J.;
RT "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT newly identified members.";
RL Tissue Antigens 71:187-192(2008).
CC -!- FUNCTION: Antigen, recognized on melanoma by autologous cytolytic T-
CC lymphocytes.
CC -!- INTERACTION:
CC Q13066; Q96IK5: GMCL1; NbExp=6; IntAct=EBI-12329121, EBI-2548508;
CC Q13066; Q14749: GNMT; NbExp=3; IntAct=EBI-12329121, EBI-744239;
CC -!- TISSUE SPECIFICITY: Expressed in a variety of tumor tissues but not in
CC normal tissues, except testis. {ECO:0000269|PubMed:7544395}.
CC -!- MISCELLANEOUS: This gene belongs to a family of genes organized in
CC clustered repeats. They have a high degree of predicted sequence
CC identity, but differ by scattered single nucleotide substitution. Their
CC sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY
CC which is recognized by cytotoxic T-cells.
CC -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC sequences, but the high identity of the GAGE members made impossible to
CC separate products of paralogous genes from polymorph products.
CC PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC identified genes and their products. {ECO:0000305}.
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DR EMBL; U19143; AAA82745.1; -; mRNA.
DR EMBL; BX649339; CAI95424.1; -; Genomic_DNA.
DR EMBL; BX649339; CAI95425.1; -; Genomic_DNA.
DR EMBL; BC069309; AAH69309.1; -; mRNA.
DR EMBL; BC069558; AAH69558.1; -; mRNA.
DR EMBL; BC113926; AAI13927.1; -; mRNA.
DR RefSeq; NP_001091881.1; NM_001098411.3.
DR RefSeq; NP_001463.1; NM_001472.2.
DR AlphaFoldDB; Q13066; -.
DR BioGRID; 108847; 3.
DR BioGRID; 570105; 1.
DR IntAct; Q13066; 2.
DR iPTMnet; Q13066; -.
DR PhosphoSitePlus; Q13066; -.
DR BioMuta; HGNC:31957; -.
DR DMDM; 3023872; -.
DR jPOST; Q13066; -.
DR MassIVE; Q13066; -.
DR MaxQB; Q13066; -.
DR PaxDb; Q13066; -.
DR PeptideAtlas; Q13066; -.
DR TopDownProteomics; Q13066; -.
DR DNASU; 2574; -.
DR GeneID; 2574; -.
DR GeneID; 645037; -.
DR KEGG; hsa:2574; -.
DR KEGG; hsa:645037; -.
DR CTD; 2574; -.
DR CTD; 645037; -.
DR DisGeNET; 2574; -.
DR DisGeNET; 645037; -.
DR GeneCards; GAGE2B; -.
DR GeneCards; GAGE2C; -.
DR HGNC; HGNC:31957; GAGE2B.
DR HGNC; HGNC:31958; GAGE2C.
DR MIM; 300595; gene.
DR MIM; 300726; gene.
DR neXtProt; NX_Q13066; -.
DR PharmGKB; PA162389260; -.
DR InParanoid; Q13066; -.
DR PhylomeDB; Q13066; -.
DR TreeFam; TF340669; -.
DR PathwayCommons; Q13066; -.
DR SignaLink; Q13066; -.
DR BioGRID-ORCS; 2574; 1 hit in 36 CRISPR screens.
DR BioGRID-ORCS; 645037; 6 hits in 86 CRISPR screens.
DR Pharos; Q13066; Tdark.
DR PRO; PR:Q13066; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q13066; protein.
DR InterPro; IPR031320; GAGE.
DR InterPro; IPR008625; GAGE_fam.
DR PANTHER; PTHR14047; PTHR14047; 1.
DR Pfam; PF05831; GAGE; 1.
DR SMART; SM01379; GAGE; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..116
FT /note="G antigen 2B/2C"
FT /id="PRO_0000148340"
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 116 AA; 12786 MW; DD305D5CA29AF19A CRC64;
MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ DPAAAQEGED
EGASAGQGPK PEAHSQEQGH PQTGCECEDG PDGQEMDPPN PEEVKTPEEG EKQSQC
