ID   GAG2E_HUMAN             Reviewed;         110 AA.
AC   Q4V326; A0A087WUD6; A6NFB1;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 2.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=G antigen 2E;
DE            Short=GAGE-2E;
GN   Name=GAGE2E;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2]
RP   GAGE FAMILY.
RX   PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA   Gjerstorff M.F., Ditzel H.J.;
RT   "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT   newly identified members.";
RL   Tissue Antigens 71:187-192(2008).
CC   -!- MISCELLANEOUS: This gene belongs to a multigene family expressed in a
CC       large variety of tumors whereas in normal tissues, expression is
CC       restricted to germ cells. These genes organized in clustered repeats,
CC       have a high degree of predicted sequence identity, but differ by
CC       scattered single nucleotide substitution. Their sequences contain
CC       either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized
CC       by cytotoxic T-cells.
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC   -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC       sequences, but the high identity of the GAGE members made impossible to
CC       separate products of paralogous genes from polymorph products.
CC       PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC       identified genes and their products. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAI95421.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; BX649339; CAI95421.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC233302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q4V326; -.
DR   BioGRID; 117809; 35.
DR   IntAct; Q4V326; 1.
DR   PhosphoSitePlus; Q4V326; -.
DR   BioMuta; GAGE2E; -.
DR   DMDM; 74753567; -.
DR   jPOST; Q4V326; -.
DR   MassIVE; Q4V326; -.
DR   PaxDb; Q4V326; -.
DR   PeptideAtlas; Q4V326; -.
DR   PRIDE; Q4V326; -.
DR   Antibodypedia; 78924; 9 antibodies from 2 providers.
DR   DNASU; 26749; -.
DR   Ensembl; ENST00000621907.1; ENSP00000478568.1; ENSG00000275113.1.
DR   GeneCards; GAGE2E; -.
DR   HGNC; HGNC:31960; GAGE2E.
DR   HPA; ENSG00000275113; Group enriched (stomach, testis).
DR   MIM; 300736; gene.
DR   neXtProt; NX_Q4V326; -.
DR   PharmGKB; PA162389276; -.
DR   VEuPathDB; HostDB:ENSG00000275113; -.
DR   GeneTree; ENSGT00940000153097; -.
DR   InParanoid; Q4V326; -.
DR   PhylomeDB; Q4V326; -.
DR   TreeFam; TF340669; -.
DR   PathwayCommons; Q4V326; -.
DR   SignaLink; Q4V326; -.
DR   Pharos; Q4V326; Tdark.
DR   PRO; PR:Q4V326; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q4V326; protein.
DR   Bgee; ENSG00000275113; Expressed in sural nerve and 76 other tissues.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047; PTHR14047; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..110
FT                   /note="G antigen 2E"
FT                   /id="PRO_0000395446"
FT   REGION          1..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        19
FT                   /note="Q -> E (in Ref. 1; CAI95421)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        75
FT                   /note="H -> D (in Ref. 1; CAI95421)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   110 AA;  12217 MW;  3D6336CFA9B6BBE8 CRC64;
     MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE
     DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE