ID   GAGC_AVISC              Reviewed;         440 AA.
AC   P05433; Q85486;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   02-JUN-2021, entry version 99.
DE   RecName: Full=P47(GAG-CRK) protein;
OS   Avian sarcoma virus (strain CT10).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Alpharetrovirus.
OX   NCBI_TaxID=11878;
OH   NCBI_TaxID=8976; Galliformes.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2450282; DOI=10.1038/332272a0;
RA   Mayer B.J., Hamaguchi M., Hanafusa H.;
RT   "A novel viral oncogene with structural similarity to phospholipase C.";
RL   Nature 332:272-275(1988).
CC   -!- DOMAIN: Late-budding domains (L domains) are short sequence motifs
CC       essential for viral particle budding. They recruit proteins of the host
CC       ESCRT machinery (Endosomal Sorting Complex Required for Transport) or
CC       ESCRT-associated proteins. Gag contains one L domain: a PPXY motif
CC       which potentially interacts with the WW domain 3 of NEDD4 E3 ubiquitin
CC       ligase (Potential). {ECO:0000305}.
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DR   EMBL; Y00302; CAA68407.1; -; Genomic_RNA.
DR   PIR; A29851; A29851.
DR   PIR; B29851; TVFV10.
DR   SMR; P05433; -.
DR   IntAct; P05433; 1.
DR   MINT; P05433; -.
DR   Proteomes; UP000149007; Genome.
DR   GO; GO:0039702; P:viral budding via host ESCRT complex; IEA:UniProtKB-KW.
DR   CDD; cd11758; SH3_CRK_N; 1.
DR   Gene3D; 1.10.150.90; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR035457; CRK_SH3_N.
DR   InterPro; IPR004028; Gag_M.
DR   InterPro; IPR012344; Matrix_HIV/RSV_N.
DR   InterPro; IPR010999; Retrovr_matrix.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF02813; Retro_M; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF47836; SSF47836; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Host-virus interaction; Oncogene; SH2 domain; SH3 domain; Viral budding;
KW   Viral budding via the host ESCRT complexes; Viral release from host cell.
FT   CHAIN           1..440
FT                   /note="P47(GAG-CRK) protein"
FT                   /id="PRO_0000125473"
FT   DOMAIN          248..354
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   DOMAIN          368..428
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REGION          1..208
FT                   /note="Gag first part"
FT   REGION          183..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          209..437
FT                   /note="CRK"
FT   REGION          438..440
FT                   /note="Gag second part"
FT   MOTIF           174..177
FT                   /note="PPXY motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   440 AA;  47176 MW;  0DB543862E8982AC CRC64;
     MEAVIKVISS ACKTYCGKTS PSKKEIGAML SLLQKEGLLM SPSDLYSPRS WDPITAALTQ
     RAMELGKSGE LKTWGLVLGA LEAAREEQEQ VTSEQAKFWL GLGGGRVSPP GPECIEKPAT
     ERRIDKGEEV GETTVQRDAK MAPEETATPK TVGTSCYYCG AAIGCNCATA SAPPPPYVGS
     GLYPSLAGVG EQQGQGGDTP RGAEQPRAGR GAGHRGLRRP AGRGQRVRPA GGAALMAGQF
     DSEDRGSWYW GRLSRGDAVS LLQGQRHGTF LVRDSGSIPG DFVLSVSESS RVSHYIVNSL
     GPAGGRRAGG EGPGAPGLNP TRFLIGDQVF DSLPSLLEFY KIHYLDTTTL IEPVSRSRQN
     SGVILRQEEV EYVRALFDFK GNDDGDLPFK KGDILKIRDK PEEQWWNAED MDGKRGMIPV
     PYVEKCRPSS ASVSTLTGGR