ID   GAGE4_HUMAN             Reviewed;         117 AA.
AC   P0DSO3; A8MU85; Q13065; Q13068; Q6NT33;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   12-AUG-2020, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=G antigen 4 {ECO:0000305};
DE   AltName: Full=Cancer/testis antigen 4.4;
DE            Short=CT4.4;
GN   Name=GAGE4 {ECO:0000312|HGNC:HGNC:4101};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Melanoma;
RX   PubMed=7544395; DOI=10.1084/jem.182.3.689;
RA   van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.;
RT   "A new family of genes coding for an antigen recognized by autologous
RT   cytolytic T lymphocytes on a human melanoma.";
RL   J. Exp. Med. 182:689-698(1995).
RN   [2]
RP   CHARACTERIZATION OF ANTIGENIC PEPTIDES.
RX   PubMed=10397259;
RA   De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S.,
RA   Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T.,
RA   van der Bruggen P.;
RT   "Characterization of the GAGE genes that are expressed in various human
RT   cancers and in normal testis.";
RL   Cancer Res. 59:3157-3165(1999).
CC   -!- FUNCTION: Antigen, recognized on melanoma by autologous cytolytic T-
CC       lymphocytes. {ECO:0000269|PubMed:7544395}.
CC   -!- TISSUE SPECIFICITY: Expressed in a variety of tumor tissues but not in
CC       normal tissues, except testis. {ECO:0000269|PubMed:7544395}.
CC   -!- MISCELLANEOUS: This gene belongs to a family of genes organized in
CC       clustered repeats. They have a high degree of predicted sequence
CC       identity, but differ by scattered single nucleotide substitution. Their
CC       sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY
CC       which is recognized by cytotoxic T-cells. {ECO:0000269|PubMed:10397259,
CC       ECO:0000269|PubMed:7544395}.
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC   -!- CAUTION: Product of a dubious gene prediction. Van den Eynde et al
CC       (PubMed:7544395) identified this gene on chromosome X, however it is
CC       not currently present in the reference genome assembly (GRCh38/hg38).
CC       {ECO:0000305}.
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DR   EMBL; U19145; AAA82747.1; -; mRNA.
DR   RefSeq; NP_001465.1; NM_001474.1.
DR   AlphaFoldDB; P0DSO3; -.
DR   MassIVE; P0DSO3; -.
DR   PeptideAtlas; P0DSO3; -.
DR   DNASU; 2576; -.
DR   GeneID; 2576; -.
DR   KEGG; hsa:2576; -.
DR   CTD; 2576; -.
DR   GeneCards; GAGE4; -.
DR   HGNC; HGNC:4101; GAGE4.
DR   neXtProt; NX_P0DSO3; -.
DR   Proteomes; UP000005640; Unplaced.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047; PTHR14047; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..117
FT                   /note="G antigen 4"
FT                   /id="PRO_0000450574"
FT   REGION          1..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..117
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   117 AA;  12956 MW;  365ED71B2F9DC7AD CRC64;
     MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE
     DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC