GAGE5_HUMAN
ID GAGE5_HUMAN Reviewed; 117 AA.
AC Q13069; Q6FG72;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=G antigen 5;
DE Short=GAGE-5;
DE AltName: Full=Cancer/testis antigen 4.5;
DE Short=CT4.5;
GN Name=GAGE5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Melanoma;
RX PubMed=7544395; DOI=10.1084/jem.182.3.689;
RA van den Eynde B., Peeters O., de Backer O., Gaugler B., Lucas S., Boon T.;
RT "A new family of genes coding for an antigen recognized by autologous
RT cytolytic T lymphocytes on a human melanoma.";
RL J. Exp. Med. 182:689-698(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P.,
RA Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y.,
RA LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP CHARACTERIZATION OF ANTIGENIC PEPTIDES.
RX PubMed=10397259;
RA De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S.,
RA Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T.,
RA van der Bruggen P.;
RT "Characterization of the GAGE genes that are expressed in various human
RT cancers and in normal testis.";
RL Cancer Res. 59:3157-3165(1999).
RN [5]
RP GAGE FAMILY.
RX PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA Gjerstorff M.F., Ditzel H.J.;
RT "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT newly identified members.";
RL Tissue Antigens 71:187-192(2008).
CC -!- INTERACTION:
CC Q13069; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-745702, EBI-10172181;
CC Q13069; Q96IK5: GMCL1; NbExp=6; IntAct=EBI-745702, EBI-2548508;
CC Q13069; Q8NEA9: GMCL2; NbExp=4; IntAct=EBI-745702, EBI-745707;
CC Q13069; Q9NYB0: TERF2IP; NbExp=2; IntAct=EBI-745702, EBI-750109;
CC -!- TISSUE SPECIFICITY: Expressed in a variety of tumor tissues but not in
CC normal tissues, except testis.
CC -!- MISCELLANEOUS: This gene belongs to a family of genes organized in
CC clustered repeats. They have a high degree of predicted sequence
CC identity, but differ by scattered single nucleotide substitution. Their
CC sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY
CC which is recognized by cytotoxic T-cells.
CC -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC sequences, but the high identity of the GAGE members made impossible to
CC separate products of paralogous genes from polymorph products.
CC PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC identified genes and their products. {ECO:0000305}.
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DR EMBL; U19146; AAA82748.1; -; mRNA.
DR EMBL; CR542236; CAG47032.1; -; mRNA.
DR EMBL; BC024914; AAH24914.1; -; mRNA.
DR RefSeq; NP_001465.1; NM_001474.1.
DR RefSeq; NP_001466.1; NM_001475.1.
DR AlphaFoldDB; Q13069; -.
DR BioGRID; 108850; 51.
DR IntAct; Q13069; 4.
DR MINT; Q13069; -.
DR iPTMnet; Q13069; -.
DR PhosphoSitePlus; Q13069; -.
DR BioMuta; HGNC:4102; -.
DR jPOST; Q13069; -.
DR MassIVE; Q13069; -.
DR MaxQB; Q13069; -.
DR PeptideAtlas; Q13069; -.
DR PRIDE; Q13069; -.
DR TopDownProteomics; Q13069; -.
DR DNASU; 2576; -.
DR GeneID; 2576; -.
DR GeneID; 2577; -.
DR KEGG; hsa:2576; -.
DR KEGG; hsa:2577; -.
DR CTD; 2576; -.
DR CTD; 2577; -.
DR DisGeNET; 2576; -.
DR DisGeNET; 2577; -.
DR GeneCards; GAGE5; -.
DR HGNC; HGNC:4102; GAGE5.
DR MIM; 300598; gene.
DR neXtProt; NX_Q13069; -.
DR PharmGKB; PA28517; -.
DR eggNOG; ENOG502SZ68; Eukaryota.
DR InParanoid; Q13069; -.
DR PathwayCommons; Q13069; -.
DR SignaLink; Q13069; -.
DR BioGRID-ORCS; 2576; 1 hit in 12 CRISPR screens.
DR BioGRID-ORCS; 2577; 1 hit in 18 CRISPR screens.
DR Pharos; Q13069; Tdark.
DR PRO; PR:Q13069; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q13069; protein.
DR InterPro; IPR031320; GAGE.
DR InterPro; IPR008625; GAGE_fam.
DR PANTHER; PTHR14047; PTHR14047; 1.
DR Pfam; PF05831; GAGE; 1.
DR SMART; SM01379; GAGE; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..117
FT /note="G antigen 5"
FT /id="PRO_0000148343"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 23
FT /note="V -> M (in Ref. 2; CAG47032)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 117 AA; 12924 MW; 234A865E2ECDDD06 CRC64;
MSWRGRSTYY WPRPRRYVQP PEVIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE
DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC
