ID   GAGE7_HUMAN             Reviewed;         117 AA.
AC   O76087; B7ZM13; Q4V324;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=G antigen 7;
DE            Short=GAGE-7;
DE   AltName: Full=AL4;
DE   AltName: Full=Cancer/testis antigen 4.7;
DE            Short=CT4.7;
DE   AltName: Full=GAGE-12I;
DE   AltName: Full=GAGE-7B;
DE   AltName: Full=GAGE-8;
GN   Name=GAGE7; Synonyms=GAGE12I, GAGE7B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9651357; DOI=10.1074/jbc.273.28.17618;
RA   Chen M.E., Lin S.-H., Chung L.W.K., Sikes R.A.;
RT   "Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed
RT   in the LNCaP prostate cancer progression model that share homology with
RT   melanoma-associated antigens.";
RL   J. Biol. Chem. 273:17618-17625(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=10397259;
RA   De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S.,
RA   Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T.,
RA   van der Bruggen P.;
RT   "Characterization of the GAGE genes that are expressed in various human
RT   cancers and in normal testis.";
RL   Cancer Res. 59:3157-3165(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   GAGE FAMILY.
RX   PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA   Gjerstorff M.F., Ditzel H.J.;
RT   "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT   newly identified members.";
RL   Tissue Antigens 71:187-192(2008).
CC   -!- TISSUE SPECIFICITY: Expressed in some prostate cancer tissues but not
CC       in normal prostate tissue.
CC   -!- MISCELLANEOUS: This gene belongs to a family of genes organized in
CC       clustered repeats. They have a high degree of predicted sequence
CC       identity, but differ by scattered single nucleotide substitution. Their
CC       sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY
CC       which is recognized by cytotoxic T-cells.
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC   -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC       sequences, but the high identity of the GAGE members made impossible to
CC       separate products of paralogous genes from polymorph products.
CC       PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC       identified genes and their products. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF058988; AAC25989.1; -; mRNA.
DR   EMBL; AF055474; AAC33677.1; -; mRNA.
DR   EMBL; AF055475; AAC33678.1; -; Genomic_DNA.
DR   EMBL; BX649339; CAI95423.1; -; Genomic_DNA.
DR   EMBL; BC031628; AAH31628.1; -; mRNA.
DR   EMBL; BC104951; AAI04952.1; -; mRNA.
DR   EMBL; BC121182; AAI21183.1; -; mRNA.
DR   EMBL; BC121183; AAI21184.1; -; mRNA.
DR   EMBL; BC144193; AAI44194.1; -; mRNA.
DR   RefSeq; NP_001091875.1; NM_001098405.2.
DR   RefSeq; NP_001091879.1; NM_001098409.1.
DR   RefSeq; NP_001120817.1; NM_001127345.1.
DR   RefSeq; NP_001468.1; NM_001477.1.
DR   RefSeq; NP_066946.1; NM_021123.2.
DR   AlphaFoldDB; O76087; -.
DR   BioGRID; 108852; 1.
DR   BioGRID; 117808; 3.
DR   BioGRID; 570130; 6.
DR   BioGRID; 755635; 1.
DR   STRING; 9606.ENSP00000404123; -.
DR   iPTMnet; O76087; -.
DR   PhosphoSitePlus; O76087; -.
DR   BioMuta; HGNC:4104; -.
DR   jPOST; O76087; -.
DR   MassIVE; O76087; -.
DR   PaxDb; O76087; -.
DR   PRIDE; O76087; -.
DR   TopDownProteomics; O76087; -.
DR   Antibodypedia; 64945; 131 antibodies from 19 providers.
DR   Antibodypedia; 70742; 15 antibodies from 7 providers.
DR   DNASU; 729428; -.
DR   GeneID; 100008586; -.
DR   GeneID; 2579; -.
DR   GeneID; 26748; -.
DR   GeneID; 645073; -.
DR   GeneID; 729428; -.
DR   KEGG; hsa:100008586; -.
DR   KEGG; hsa:2579; -.
DR   KEGG; hsa:26748; -.
DR   KEGG; hsa:645073; -.
DR   KEGG; hsa:729428; -.
DR   MANE-Select; ENST00000440137.2; ENSP00000404123.1; NM_001098405.3; NP_001091875.1.
DR   MANE-Select; ENST00000445148.2; ENSP00000416249.1; NM_001098409.4; NP_001091879.1.
DR   CTD; 100008586; -.
DR   CTD; 2579; -.
DR   CTD; 26748; -.
DR   CTD; 645073; -.
DR   CTD; 729428; -.
DR   DisGeNET; 100008586; -.
DR   DisGeNET; 2579; -.
DR   DisGeNET; 26748; -.
DR   DisGeNET; 645073; -.
DR   DisGeNET; 729428; -.
DR   GeneCards; GAGE7; -.
DR   HGNC; HGNC:4104; GAGE7.
DR   HPA; ENSG00000215269; Group enriched (retina, stomach).
DR   HPA; ENSG00000236362; Tissue enriched (testis).
DR   MIM; 300601; gene.
DR   MIM; 300637; gene.
DR   neXtProt; NX_O76087; -.
DR   PharmGKB; PA145148778; -.
DR   VEuPathDB; HostDB:ENSG00000215269; -.
DR   VEuPathDB; HostDB:ENSG00000236362; -.
DR   eggNOG; ENOG502SZ68; Eukaryota.
DR   HOGENOM; CLU_150116_0_0_1; -.
DR   InParanoid; O76087; -.
DR   OrthoDB; 1575904at2759; -.
DR   PhylomeDB; O76087; -.
DR   PathwayCommons; O76087; -.
DR   BioGRID-ORCS; 100008586; 3 hits in 61 CRISPR screens.
DR   BioGRID-ORCS; 2579; 3 hits in 24 CRISPR screens.
DR   BioGRID-ORCS; 26748; 3 hits in 92 CRISPR screens.
DR   BioGRID-ORCS; 645073; 3 hits in 35 CRISPR screens.
DR   Pharos; O76087; Tbio.
DR   PRO; PR:O76087; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; O76087; protein.
DR   ExpressionAtlas; O76087; baseline.
DR   Genevisible; O76087; HS.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047; PTHR14047; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..117
FT                   /note="G antigen 7"
FT                   /id="PRO_0000148345"
FT   REGION          1..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..117
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   117 AA;  12978 MW;  365ED8D41361C7AD CRC64;
     MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE
     DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC