GAG_AVEV2
ID GAG_AVEV2 Reviewed; 188 AA.
AC P06937;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1988, sequence version 1.
DT 29-SEP-2021, entry version 83.
DE RecName: Full=Gag polyprotein;
DE AltName: Full=Core polyprotein;
DE Contains:
DE RecName: Full=Matrix protein p19;
DE Contains:
DE RecName: Full=p2A;
DE Contains:
DE RecName: Full=p2B;
DE Contains:
DE RecName: Full=p10;
DE Flags: Fragment;
GN Name=ev-2;
OS Avian endogenous rous-associated virus-0 (EV-2) (Avian retrovirus RAV-0).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Alpharetrovirus.
OX NCBI_TaxID=11949;
OH NCBI_TaxID=8976; Galliformes.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA], AND PROTEOLYTIC CLEAVAGE (GAG
RP POLYPROTEIN).
RX PubMed=2993659; DOI=10.1128/jvi.56.1.31-39.1985;
RA Vogt V.M., Pepinsky R.B., Southard L.E.;
RT "Primary structure of p19 species of avian sarcoma and leukemia viruses.";
RL J. Virol. 56:31-39(1985).
CC -!- SUBCELLULAR LOCATION: [Matrix protein p19]: Virion {ECO:0000305}.
CC -!- DOMAIN: [Gag polyprotein]: Late-budding domains (L domains) are short
CC sequence motifs essential for viral particle budding. They recruit
CC proteins of the host ESCRT machinery (Endosomal Sorting Complex
CC Required for Transport) or ESCRT-associated proteins. Gag contains one
CC L domain: a PPXY motif which potentially interacts with the WW domain 3
CC of NEDD4 E3 ubiquitin ligase (Potential). {ECO:0000305}.
CC -!- PTM: [Gag polyprotein]: Specific enzymatic cleavages in vivo yield
CC mature proteins. {ECO:0000250|UniProtKB:P03322}.
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DR EMBL; M30518; AAA42568.1; -; Genomic_RNA.
DR PIR; B25317; B25317.
DR SMR; P06937; -.
DR GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR GO; GO:0039702; P:viral budding via host ESCRT complex; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.90; -; 1.
DR InterPro; IPR004028; Gag_M.
DR InterPro; IPR012344; Matrix_HIV/RSV_N.
DR InterPro; IPR010999; Retrovr_matrix.
DR Pfam; PF02813; Retro_M; 1.
DR SUPFAM; SSF47836; SSF47836; 1.
PE 1: Evidence at protein level;
KW Host-virus interaction; Viral budding;
KW Viral budding via the host ESCRT complexes; Viral matrix protein;
KW Viral release from host cell; Virion.
FT CHAIN <1..188
FT /note="Gag polyprotein"
FT /id="PRO_0000442116"
FT CHAIN <1..104
FT /note="Matrix protein p19"
FT /id="PRO_0000040813"
FT CHAIN 105..115
FT /note="p2A"
FT /id="PRO_0000442117"
FT CHAIN 116..126
FT /note="p2B"
FT /id="PRO_0000442118"
FT CHAIN 127..188
FT /note="p10"
FT /id="PRO_0000040814"
FT REGION 77..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 121..124
FT /note="PPXY motif"
FT /evidence="ECO:0000250|UniProtKB:P03322"
FT SITE 104..105
FT /note="Cleavage; by viral protease p15"
FT /evidence="ECO:0000269|PubMed:2993659"
FT SITE 115..116
FT /note="Cleavage; by viral protease p15"
FT /evidence="ECO:0000250|UniProtKB:P03322"
FT SITE 126..127
FT /note="Cleavage; by viral protease p15"
FT /evidence="ECO:0000250|UniProtKB:P03322"
FT NON_TER 1
FT NON_TER 188
SQ SEQUENCE 188 AA; 19356 MW; 8034F7939D44F1D9 CRC64;
DPITAALSQR AMVLGKSGEL KTWGLVLGAL KAAREEQVTS EQAKFWLGLG GGRVSPPGPE
CIEKPATERR IDKGEEVGET TVQRDAKMAP EETATPKTVG TSCYHCGTAI GCNCATASAP
PPPYVGSGLY PSLAGVGEQQ GQGGDTPRGA EQPRAEPGHA GLAPGPALTD WARIREELAS
TGPPVVAM
