GAG_FIVWO
ID GAG_FIVWO Reviewed; 450 AA.
AC Q05313;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 23-FEB-2022, entry version 90.
DE RecName: Full=Gag polyprotein;
DE Contains:
DE RecName: Full=Matrix protein p15;
DE Short=MA;
DE Contains:
DE RecName: Full=Capsid protein p24;
DE Short=CA;
DE Contains:
DE RecName: Full=p1;
DE Contains:
DE RecName: Full=Nucleocapsid protein p13;
DE Short=NC;
GN Name=gag;
OS Feline immunodeficiency virus (isolate Wo) (FIV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=45409;
OH NCBI_TaxID=9681; Felidae (cat family).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8380668; DOI=10.1006/viro.1993.1083;
RA Pancino G., Fossati I., Chappey C., Castelot S., Hurtrel B., Maraillon A.,
RA Klatzmann D., Sonigo P.;
RT "Structure and variations of feline immunodeficiency virus envelope
RT glycoproteins.";
RL Virology 192:659-662(1993).
CC -!- FUNCTION: Matrix protein p15 forms the outer shell of the core of the
CC virus, lining the inner surface of the viral membrane. {ECO:0000250}.
CC -!- FUNCTION: Capsid protein p24 forms the conical core of the virus that
CC encapsulates the genomic RNA-nucleocapsid complex. {ECO:0000250}.
CC -!- FUNCTION: Nucleocapsid protein p13 encapsulates and protects viral
CC dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc
CC fingers (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Matrix protein p15]: Virion {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Capsid protein p24]: Virion {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Nucleocapsid protein p13]: Virion {ECO:0000305}.
CC -!- DOMAIN: Late-budding domains (L domains) are short sequence motifs
CC essential for viral particle budding. They recruit proteins of the host
CC ESCRT machinery (Endosomal Sorting Complex Required for Transport) or
CC ESCRT-associated proteins. Nucleocapsid protein p13 contains one L
CC domain: a PTAP/PSAP motif, which interacts with the UEV domain of
CC TSG101 (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the feline lentivirus group gag polyprotein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L06136; AAA43069.1; -; Genomic_DNA.
DR EMBL; L06311; AAA43070.1; -; Genomic_DNA.
DR SMR; Q05313; -.
DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0039702; P:viral budding via host ESCRT complex; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1200.30; -; 1.
DR Gene3D; 1.10.150.90; -; 1.
DR Gene3D; 1.10.375.10; -; 1.
DR InterPro; IPR045345; Gag_p24_C.
DR InterPro; IPR012344; Matrix_HIV/RSV_N.
DR InterPro; IPR008916; Retrov_capsid_C.
DR InterPro; IPR008919; Retrov_capsid_N.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR Pfam; PF19317; Gag_p24_C; 1.
DR Pfam; PF00098; zf-CCHC; 2.
DR SMART; SM00343; ZnF_C2HC; 2.
DR SUPFAM; SSF47943; SSF47943; 1.
DR SUPFAM; SSF57756; SSF57756; 1.
DR PROSITE; PS50158; ZF_CCHC; 2.
PE 3: Inferred from homology;
KW Capsid protein; Host-virus interaction; Metal-binding; Repeat;
KW Viral budding; Viral budding via the host ESCRT complexes;
KW Viral matrix protein; Viral nucleoprotein; Viral release from host cell;
KW Virion; Virion maturation; Zinc; Zinc-finger.
FT CHAIN 1..135
FT /note="Matrix protein p15"
FT /id="PRO_0000038793"
FT CHAIN 136..357
FT /note="Capsid protein p24"
FT /id="PRO_0000272318"
FT PEPTIDE 358..366
FT /note="p1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000038794"
FT CHAIN 367..450
FT /note="Nucleocapsid protein p13"
FT /id="PRO_0000038795"
FT ZN_FING 375..392
FT /note="CCHC-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT ZN_FING 394..411
FT /note="CCHC-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 116..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 438..441
FT /note="PTAP/PSAP motif"
SQ SEQUENCE 450 AA; 49200 MW; 93BAA2FB4DA76FAC CRC64;
MGNGQGRDWK MAIKRCSNGA VGVGGKSKKF GEGNFRWAIR MANVSTGREP GDIPETLDQL
RLVICDLQER REKFGSSKEI DMAIAALKVF AVVGLLNMTV STAAAAENMY TQMGLDTRPS
TKEAGGKEEG PPQAYPIQTV NGTTQYVALD PKMVSIFMEK AREGLGGEEV QLWFTAFSAN
LTPTDMATLI MARPGCAADK EILDESLKQL TAEYDRTHPP DGPRPLPYFT AAEIMGIGLT
QEQQAEARFA PARMQCRAWY LEALGKLAAI KAKSPRAVQL RQGAKEDYSS FIDRLFAQID
QEQNTAEVKL YLKQSLSIAN ANADCKKAMS HLKPESTLEE KLRACQEIGF PGYKMQLLAE
ALTKVQVVQS KGPGPVCFNC KRPGHLARQC RDVKKCNKCG KPGHLAAKCW QGGKKNSGNW
KAGRAAAPVN QVQQAVMPSA PPMEEKLLDL
