GAK1B_MOUSE
ID GAK1B_MOUSE Reviewed; 517 AA.
AC Q3UPI1; B3VSA6; Q6PGJ9; Q8C781; Q9ET25;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Golgi-associated kinase 1B {ECO:0000305};
DE AltName: Full=Expressed in nerve and epithelium during development {ECO:0000303|PubMed:18956345};
DE AltName: Full=Protein FAM198B;
GN Name=GaskbB;
GN Synonyms=Ened {ECO:0000303|PubMed:18956345},
GN Fam198b {ECO:0000312|MGI:MGI:1915909};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=18956345; DOI=10.1387/ijdb.082700rm;
RA Meszaros R., Strate I., Pera E.M., Durbeej M.;
RT "Expression of the novel gene Ened during mouse and Xenopus embryonic
RT development.";
RL Int. J. Dev. Biol. 52:1119-1122(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hoppe J., Hoppe V.;
RT "Differentially expressed genes in AKR-2B fibroblasts.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q6UWH4}; Single-pass type II membrane protein
CC {ECO:0000250|UniProtKB:Q6UWH4}.
CC -!- TISSUE SPECIFICITY: At E9.5, detected in heart and midgut. At later
CC gestation stages, expressed in floor plate, peripheral nervous system,
CC lens epithelium, skin, midline dorsal aorta, lung, kidney and testis.
CC {ECO:0000269|PubMed:18956345}.
CC -!- SIMILARITY: Belongs to the GASK family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC34959.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; EU797522; ACE82567.1; -; mRNA.
DR EMBL; AF285091; AAG00502.1; -; mRNA.
DR EMBL; AK052367; BAC34959.1; ALT_INIT; mRNA.
DR EMBL; AK143522; BAE25414.1; -; mRNA.
DR EMBL; BC056975; AAH56975.1; -; mRNA.
DR CCDS; CCDS17422.1; -.
DR RefSeq; NP_573450.2; NM_133187.3.
DR RefSeq; XP_006502047.1; XM_006501984.3.
DR RefSeq; XP_006502048.1; XM_006501985.2.
DR AlphaFoldDB; Q3UPI1; -.
DR STRING; 10090.ENSMUSP00000114093; -.
DR GlyGen; Q3UPI1; 2 sites.
DR iPTMnet; Q3UPI1; -.
DR PhosphoSitePlus; Q3UPI1; -.
DR MaxQB; Q3UPI1; -.
DR PaxDb; Q3UPI1; -.
DR PRIDE; Q3UPI1; -.
DR ProteomicsDB; 275512; -.
DR Antibodypedia; 2027; 79 antibodies from 17 providers.
DR Ensembl; ENSMUST00000029567; ENSMUSP00000029567; ENSMUSG00000027955.
DR Ensembl; ENSMUST00000118853; ENSMUSP00000114093; ENSMUSG00000027955.
DR GeneID; 68659; -.
DR KEGG; mmu:68659; -.
DR UCSC; uc008pny.2; mouse.
DR CTD; 51313; -.
DR MGI; MGI:1915909; Fam198b.
DR VEuPathDB; HostDB:ENSMUSG00000027955; -.
DR eggNOG; ENOG502QU38; Eukaryota.
DR GeneTree; ENSGT00420000029769; -.
DR HOGENOM; CLU_033542_2_0_1; -.
DR InParanoid; Q3UPI1; -.
DR OMA; PPWFSAQ; -.
DR OrthoDB; 451767at2759; -.
DR PhylomeDB; Q3UPI1; -.
DR TreeFam; TF330994; -.
DR BioGRID-ORCS; 68659; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Gask1b; mouse.
DR PRO; PR:Q3UPI1; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q3UPI1; protein.
DR Bgee; ENSMUSG00000027955; Expressed in ascending aorta and 200 other tissues.
DR ExpressionAtlas; Q3UPI1; baseline and differential.
DR Genevisible; Q3UPI1; MM.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029207; FAM198.
DR PANTHER; PTHR15905; PTHR15905; 1.
DR Pfam; PF15051; FAM198; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..517
FT /note="Golgi-associated kinase 1B"
FT /id="PRO_0000288903"
FT TOPO_DOM 1..36
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..56
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..517
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 98
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 287
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 275
FT /note="V -> L (in Ref. 1; ACE82567 and 4; AAH56975)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 517 AA; 58298 MW; FA7B56FA8E3A85A5 CRC64;
MTCPDKPGQL VNWFVCSLCA PRVCKLWSSR RPRTRRNLLL GTACAIYLGF LVSQVGRGSF
QHGQATDRGP PNGHDIFKVP FSEIPLDGTL APPELQGNGS TLQPNVVYIT LRSKRSKPAN
IRGTVKPKRR KKYAVASAAP DQEVLVRPSL IQQEAARAAD AEVPGYVQGY LTKVGERPWR
VLRGPGVRTR GSNLQQPRAR ESNIRIYSES APSWLSKEDI RRMRLLADSE VASILPISKS
GTRLLVLEGS TSGSVPGCGP SPCGLLKQPL DMSEVFAFHL DRILGLNRTL PSVSRKLEFI
QDGRPRPIIL WDSSLASASN DSHSSVKITW GTYQRLLKQK CWLNGRVPRP EWDCTEIHHH
EWSKMALFDF LLQIYNRLDT NCCGFRPRKE DACIQNGLRS NCEDQTSVTL AHIIQRKNDP
RHLVFINNKG FFDRSEDNLN FKLLEGIREF PESAVSVLKS QHLRQKLLQS LFLDQVYWES
QGGRQGIEKL IDVIERRARI LITYINAHGA RVLPMNE
