GAL1_CANAX
ID GAL1_CANAX Reviewed; 515 AA.
AC P56091;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Galactokinase;
DE EC=2.7.1.6;
DE AltName: Full=Galactose kinase;
GN Name=GAL1;
OS Candida albicans (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=5476;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 11651 / B792 / 171D;
RA Grindle S., Magee B.B., Gorman J.A.;
RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate
CC + H(+); Xref=Rhea:RHEA:13553, ChEBI:CHEBI:15378, ChEBI:CHEBI:28061,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58336, ChEBI:CHEBI:456216; EC=2.7.1.6;
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
CC {ECO:0000305}.
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DR EMBL; AF006591; AAB62568.1; -; Genomic_DNA.
DR AlphaFoldDB; P56091; -.
DR SMR; P56091; -.
DR PRIDE; P56091; -.
DR VEuPathDB; FungiDB:C1_02130C_A; -.
DR VEuPathDB; FungiDB:CAWG_01170; -.
DR UniPathway; UPA00214; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004335; F:galactokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.230.10; -; 1.
DR InterPro; IPR000705; Galactokinase.
DR InterPro; IPR019741; Galactokinase_CS.
DR InterPro; IPR019539; GalKase_N.
DR InterPro; IPR013750; GHMP_kinase_C_dom.
DR InterPro; IPR036554; GHMP_kinase_C_sf.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR006203; GHMP_knse_ATP-bd_CS.
DR InterPro; IPR006206; Mevalonate/galactokinase.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR Pfam; PF10509; GalKase_gal_bdg; 1.
DR Pfam; PF08544; GHMP_kinases_C; 1.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PIRSF; PIRSF000530; Galactokinase; 1.
DR PRINTS; PR00473; GALCTOKINASE.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55060; SSF55060; 1.
DR TIGRFAMs; TIGR00131; gal_kin; 1.
DR PROSITE; PS00106; GALACTOKINASE; 1.
DR PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE 3: Inferred from homology;
KW ATP-binding; Carbohydrate metabolism; Galactose metabolism; Kinase;
KW Nucleotide-binding; Transferase.
FT CHAIN 1..515
FT /note="Galactokinase"
FT /id="PRO_0000184652"
FT ACT_SITE 205
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 153..163
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT SITE 48
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000250"
SQ SEQUENCE 515 AA; 57066 MW; A4133EC369A53D00 CRC64;
MSVPTFDDLS FYSNDQELTK SRYLKLVEIF QSNFPNASID FFARSPGRVN LIGDHIDYNF
FPVLPMAISA DVIVAVNVND EPEIVITHTD SKNFAKETIP LTNNNDGFEI DSQHHSWANY
FKCALIVANN YLTEQNLKGQ LKGMKLTFDG NVPTGGGLSS SAAFCVASTL AILHANGVKD
ITKADLTRIT VVCEHYVGVN TGGMDQCASV YGEPDKALLI QFKPKLIGKP FKFPVENLTF
VITNSLQVSN KHETAPIHYN LRVVEMAIAA DVLVKKLNLG TLVPQDSNIG TSSLRGVMDA
VFNTCKWDGN DIDVGIDQLK KMIAIVETEL NNNQEGYTVD QCLTVLDLSL DEFKSKYLQA
YPVKFDVLKL YQRAKHVYQE SLRVLETLKL LSTTQTSSNS KDDDESFLVK FGELMNQSQS
DLDKLNESSN DKLNKICSIA LQNGSYGSRI TGAGWGGSIV HLTTLDKSKQ LIQGLIKNYY
QLEFPSIKLD ELLNDAIIDS KPSMGSCIVT TKFLQ
