ID   GAL1_CANPA              Reviewed;         504 AA.
AC   O42821;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Galactokinase;
DE            EC=2.7.1.6;
DE   AltName: Full=Galactose kinase;
GN   Name=GAL1;
OS   Candida parapsilosis (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=5480;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SR23 / CBS 7157;
RA   Nosek J.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate
CC         + H(+); Xref=Rhea:RHEA:13553, ChEBI:CHEBI:15378, ChEBI:CHEBI:28061,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58336, ChEBI:CHEBI:456216; EC=2.7.1.6;
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
CC       {ECO:0000305}.
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DR   EMBL; Y14704; CAA75006.1; -; Genomic_DNA.
DR   AlphaFoldDB; O42821; -.
DR   SMR; O42821; -.
DR   CGD; CAL0000150901; GAL1.
DR   VEuPathDB; FungiDB:CPAR2_106130; -.
DR   UniPathway; UPA00214; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004335; F:galactokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.230.10; -; 1.
DR   InterPro; IPR000705; Galactokinase.
DR   InterPro; IPR019741; Galactokinase_CS.
DR   InterPro; IPR019539; GalKase_N.
DR   InterPro; IPR013750; GHMP_kinase_C_dom.
DR   InterPro; IPR036554; GHMP_kinase_C_sf.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR006203; GHMP_knse_ATP-bd_CS.
DR   InterPro; IPR006206; Mevalonate/galactokinase.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   Pfam; PF10509; GalKase_gal_bdg; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF000530; Galactokinase; 1.
DR   PRINTS; PR00473; GALCTOKINASE.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55060; SSF55060; 1.
DR   TIGRFAMs; TIGR00131; gal_kin; 1.
DR   PROSITE; PS00106; GALACTOKINASE; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Galactose metabolism; Kinase;
KW   Nucleotide-binding; Transferase.
FT   CHAIN           1..504
FT                   /note="Galactokinase"
FT                   /id="PRO_0000184654"
FT   ACT_SITE        200
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         148..158
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   SITE            47
FT                   /note="Transition state stabilizer"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   504 AA;  55598 MW;  4CE9ACA3E1DD328E CRC64;
     MSVPKFNDLS FYSDPSAHKS RYANLVKTFK SKYPNDEIEF FARSPGRVNL IGDHIDYNYF
     PVLPMAIEVD VVAAVSTNNN DMIVIANTDS AKFPKETVSL AEEFTIDREH HTWANYFKCG
     LIVASKFLQE KAMTKLKGMN ITFSGTVPTG GGLSSSAAFC VASTLAVLYA NGVEDISKAD
     LTRITVVSEH YLGLNNGGMD QCASVYGEQG KALFIQFKPQ LKGTPFEFPV KNLTFVITNS
     LQVSNKYETA PIHYNLRVVE MAIAGDLLAK KLNVEGKEGI VKDSNVDTYS LRGVMDGYCG
     AWDGEDLDVG VVHLEKMIDV VGKTLTKEGG YTVEQCCEEM GLTPEEFHSR YLKKIPVKFD
     VLKLYERALH VYRESLRVLK TLQLLSTVVD ASQFLQTFGS LMNESQHDLD ILNESSNPKL
     NEICSIALAN GAYGSRVTGA GWGGSIVHLT TTENLPKLTK SLEAYYKREF PGITDEEIRE
     AVIDSKPATG SCLVKLDFSH ALQG