ID   3NO25_NAJNA             Reviewed;          62 AA.
AC   P29179;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Weak neurotoxin 5 {ECO:0000305|PubMed:2060629};
OS   Naja naja (Indian cobra).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX   NCBI_TaxID=35670;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=2060629; DOI=10.1016/0014-5793(91)80764-t;
RA   Shafqat J., Siddiqi A.R., Zaidi Z.H., Joernvall H.;
RT   "Extensive multiplicity of the miscellaneous type of neurotoxins from the
RT   venom of the cobra Naja naja naja and structural characterization of major
RT   components.";
RL   FEBS Lett. 284:70-72(1991).
CC   -!- FUNCTION: Binds with low affinity to muscular (alpha-1-beta-1-delta-
CC       epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) and very low affinity to neuronal
CC       (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR).
CC       {ECO:0000250|UniProtKB:O42255}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2060629}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:2060629}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Ancestral
CC       subfamily. Orphan group II sub-subfamily. {ECO:0000305}.
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DR   PIR; S15871; S15871.
DR   AlphaFoldDB; P29179; -.
DR   SMR; P29179; -.
DR   PRIDE; P29179; -.
DR   Proteomes; UP000694559; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Reference proteome; Secreted;
KW   Toxin.
FT   CHAIN           1..62
FT                   /note="Weak neurotoxin 5"
FT                   /evidence="ECO:0000269|PubMed:2060629"
FT                   /id="PRO_0000093637"
FT   DISULFID        3..24
FT                   /evidence="ECO:0000250|UniProtKB:Q8AY51"
FT   DISULFID        6..11
FT                   /evidence="ECO:0000250|UniProtKB:Q8AY51"
FT   DISULFID        17..40
FT                   /evidence="ECO:0000250|UniProtKB:Q8AY51"
FT   DISULFID        44..54
FT                   /evidence="ECO:0000250|UniProtKB:Q8AY51"
FT   DISULFID        55..60
FT                   /evidence="ECO:0000250|UniProtKB:Q8AY51"
SQ   SEQUENCE   62 AA;  6943 MW;  2BA3EB6FDF2BDCF9 CRC64;
     LTCLICPEKY CNKVHTCLNG ENICFKRFNR ILGKRYDLGC AATCPTVKTG IVQCCSTDKC
     NH