ID   GALA_BOVIN              Reviewed;         123 AA.
AC   P11242; A0JNM9;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Galanin peptides;
DE   Contains:
DE     RecName: Full=Galanin;
DE   Contains:
DE     RecName: Full=Galanin message-associated peptide;
DE              Short=GMAP;
DE   Flags: Precursor;
GN   Name=GAL; Synonyms=GALN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AMINO-ACID COMPOSITION OF GALANIN, AND
RP   AMIDATION AT ALA-61.
RX   PubMed=2455659; DOI=10.1016/0014-5793(88)80125-x;
RA   Roekaeus A., Carlquist M.;
RT   "Nucleotide sequence analysis of cDNAs encoding a bovine galanin precursor
RT   protein in the adrenal medulla and chemical isolation of bovine gut
RT   galanin.";
RL   FEBS Lett. 234:400-406(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
RX   PubMed=7509811; DOI=10.1016/s0021-9258(17)37450-1;
RA   Anouar Y., Macarthur L., Cohen J., Iacangelo A.L., Eiden L.E.;
RT   "Identification of a TPA-responsive element mediating preferential
RT   transactivation of the galanin gene promoter in chromaffin cells.";
RL   J. Biol. Chem. 269:6823-6831(1994).
CC   -!- FUNCTION: Endocrine hormone of the central and peripheral nervous
CC       systems that binds and activates the G protein-coupled receptors GALR1,
CC       GALR2, and GALR3. This small neuropeptide may regulate diverse
CC       physiologic functions including contraction of smooth muscle of the
CC       gastrointestinal and genitourinary tract, growth hormone and insulin
CC       release and adrenal secretion. {ECO:0000250|UniProtKB:P07480,
CC       ECO:0000250|UniProtKB:P22466}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P07480,
CC       ECO:0000250|UniProtKB:P22466}.
CC   -!- SIMILARITY: Belongs to the galanin family. {ECO:0000305}.
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DR   EMBL; X12582; CAA31094.1; -; mRNA.
DR   EMBL; BC126798; AAI26799.1; -; mRNA.
DR   EMBL; S68957; AAD14027.1; -; Genomic_DNA.
DR   PIR; S01011; RHBOG.
DR   RefSeq; NP_776339.1; NM_173914.2.
DR   AlphaFoldDB; P11242; -.
DR   STRING; 9913.ENSBTAP00000012362; -.
DR   PaxDb; P11242; -.
DR   PRIDE; P11242; -.
DR   Ensembl; ENSBTAT00000012362; ENSBTAP00000012362; ENSBTAG00000009393.
DR   GeneID; 280799; -.
DR   KEGG; bta:280799; -.
DR   CTD; 51083; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009393; -.
DR   VGNC; VGNC:29212; GAL.
DR   eggNOG; ENOG502RZ1E; Eukaryota.
DR   GeneTree; ENSGT00390000009663; -.
DR   HOGENOM; CLU_166244_0_0_1; -.
DR   InParanoid; P11242; -.
DR   OMA; PEDDMKP; -.
DR   OrthoDB; 1518030at2759; -.
DR   TreeFam; TF335850; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000009393; Expressed in ascending colon and 71 other tissues.
DR   ExpressionAtlas; P11242; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR   GO; GO:0004966; F:galanin receptor activity; ISS:UniProtKB.
DR   GO; GO:0031763; F:galanin receptor binding; IBA:GO_Central.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0031764; F:type 1 galanin receptor binding; ISS:UniProtKB.
DR   GO; GO:0031765; F:type 2 galanin receptor binding; ISS:UniProtKB.
DR   GO; GO:0031766; F:type 3 galanin receptor binding; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR008174; Galanin.
DR   InterPro; IPR008175; Galanin_pre.
DR   InterPro; IPR013068; GMAP.
DR   PANTHER; PTHR16839; PTHR16839; 1.
DR   Pfam; PF01296; Galanin; 1.
DR   Pfam; PF06540; GMAP; 1.
DR   PRINTS; PR00273; GALANIN.
DR   SMART; SM00071; Galanin; 1.
DR   PROSITE; PS00861; GALANIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW   Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..30
FT                   /id="PRO_0000010443"
FT   PEPTIDE         33..61
FT                   /note="Galanin"
FT                   /id="PRO_0000010444"
FT   PEPTIDE         65..123
FT                   /note="Galanin message-associated peptide"
FT                   /id="PRO_0000010445"
FT   REGION          53..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         61
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000269|PubMed:2455659"
FT   MOD_RES         116
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P22466"
SQ   SEQUENCE   123 AA;  13253 MW;  CA6AC1617947A9F3 CRC64;
     MPRGSVLLLA SLLLAAALSA TLGLGSPVKE KRGWTLNSAG YLLGPHALDS HRSFQDKHGL
     AGKRELEPED EARPGSFDRP LAENNVVRTI IEFLTFLHLK DAGALERLPS LPTAESAEDA
     ERS