ID   GALA_CANLF              Reviewed;          54 AA.
AC   P33710;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Galanin peptides;
DE   Contains:
DE     RecName: Full=Galanin;
DE   Contains:
DE     RecName: Full=Galanin message-associated peptide;
DE              Short=GMAP;
DE   Flags: Precursor; Fragment;
GN   Name=GAL; Synonyms=GALN;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7512738; DOI=10.1016/0167-0115(94)90185-6;
RA   Boyle M.R., Verchere C.B., McKnight G.L., Mathewes S., Walker K.M.,
RA   Taborsky G.J. Jr.;
RT   "Canine galanin: sequence, expression and pancreatic effects.";
RL   Regul. Pept. 50:1-11(1994).
CC   -!- FUNCTION: Endocrine hormone of the central and peripheral nervous
CC       systems that binds and activates the G protein-coupled receptors GALR1,
CC       GALR2, and GALR3. This small neuropeptide may regulate diverse
CC       physiologic functions including contraction of smooth muscle of the
CC       gastrointestinal and genitourinary tract, growth hormone and insulin
CC       release and adrenal secretion. {ECO:0000250|UniProtKB:P07480,
CC       ECO:0000250|UniProtKB:P22466}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P07480,
CC       ECO:0000250|UniProtKB:P22466}.
CC   -!- SIMILARITY: Belongs to the galanin family. {ECO:0000305}.
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DR   EMBL; L14718; AAA30845.1; -; mRNA.
DR   PIR; I46202; I46202.
DR   AlphaFoldDB; P33710; -.
DR   STRING; 9615.ENSCAFP00000015855; -.
DR   PaxDb; P33710; -.
DR   eggNOG; ENOG502RZ1E; Eukaryota.
DR   InParanoid; P33710; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR   GO; GO:0004966; F:galanin receptor activity; ISS:UniProtKB.
DR   GO; GO:0031763; F:galanin receptor binding; IBA:GO_Central.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0031764; F:type 1 galanin receptor binding; ISS:UniProtKB.
DR   GO; GO:0031765; F:type 2 galanin receptor binding; ISS:UniProtKB.
DR   GO; GO:0031766; F:type 3 galanin receptor binding; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR008174; Galanin.
DR   InterPro; IPR008175; Galanin_pre.
DR   InterPro; IPR013068; GMAP.
DR   PANTHER; PTHR16839; PTHR16839; 1.
DR   Pfam; PF01296; Galanin; 1.
DR   Pfam; PF06540; GMAP; 1.
DR   SMART; SM00071; Galanin; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW   Reference proteome; Secreted.
FT   PEPTIDE         <1..26
FT                   /note="Galanin"
FT                   /id="PRO_0000010446"
FT   PEPTIDE         30..>54
FT                   /note="Galanin message-associated peptide"
FT                   /id="PRO_0000010447"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         26
FT                   /note="Threonine amide"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
FT   NON_TER         54
SQ   SEQUENCE   54 AA;  5668 MW;  86EC349E959C89EF CRC64;
     LNSAGYLLGP HAIDNHRSFH EKPGLTGKRE LPPEDEGRSG GFAGPLSLSE NAAV