ID   GALA_COTJA              Reviewed;         117 AA.
AC   Q9W6M9; Q9W6M8;
DT   11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT   11-FEB-2002, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Galanin peptides;
DE   Contains:
DE     RecName: Full=Galanin;
DE   Contains:
DE     RecName: Full=Galanin message-associated peptide;
DE              Short=GMAP;
DE   Flags: Precursor;
GN   Name=GAL;
OS   Coturnix japonica (Japanese quail) (Coturnix coturnix japonica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Perdicinae; Coturnix.
OX   NCBI_TaxID=93934;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain;
RX   PubMed=11108248; DOI=10.1210/endo.141.12.7827;
RA   Sakamoto H., Ubuka T., Kohchi C., Li D., Ukena K., Tsutsui K.;
RT   "Existence of galanin in lumbosacral sympathetic ganglionic neurons that
RT   project to the quail uterine oviduct.";
RL   Endocrinology 141:4402-4412(2000).
CC   -!- FUNCTION: Endocrine hormone of the central and peripheral nervous
CC       systems that binds and activates the G protein-coupled receptors GALR1,
CC       GALR2, and GALR3. This small neuropeptide may regulate diverse
CC       physiologic functions including contraction of smooth muscle of the
CC       gastrointestinal and genitourinary tract, growth hormone and insulin
CC       release and adrenal secretion. {ECO:0000250|UniProtKB:P07480,
CC       ECO:0000250|UniProtKB:P22466}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P07480,
CC       ECO:0000250|UniProtKB:P22466}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9W6M9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9W6M9-2; Sequence=VSP_001597;
CC   -!- SIMILARITY: Belongs to the galanin family. {ECO:0000305}.
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DR   EMBL; AF141936; AAD37349.1; -; mRNA.
DR   EMBL; AF141935; AAD37348.1; -; mRNA.
DR   RefSeq; XP_015719285.1; XM_015863799.1.
DR   RefSeq; XP_015719286.1; XM_015863800.1.
DR   RefSeq; XP_015719287.1; XM_015863801.1.
DR   RefSeq; XP_015719288.1; XM_015863802.1.
DR   RefSeq; XP_015719289.1; XM_015863803.1. [Q9W6M9-1]
DR   AlphaFoldDB; Q9W6M9; -.
DR   Ensembl; ENSCJPT00005031846; ENSCJPP00005023207; ENSCJPG00005018444. [Q9W6M9-2]
DR   Ensembl; ENSCJPT00005031847; ENSCJPP00005023208; ENSCJPG00005018444. [Q9W6M9-1]
DR   GeneID; 107314517; -.
DR   KEGG; cjo:107314517; -.
DR   CTD; 51083; -.
DR   GeneTree; ENSGT00390000009663; -.
DR   OrthoDB; 1518030at2759; -.
DR   Proteomes; UP000694412; Chromosome 5.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004966; F:galanin receptor activity; ISS:UniProtKB.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0031764; F:type 1 galanin receptor binding; ISS:UniProtKB.
DR   GO; GO:0031765; F:type 2 galanin receptor binding; ISS:UniProtKB.
DR   GO; GO:0031766; F:type 3 galanin receptor binding; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR008174; Galanin.
DR   InterPro; IPR008175; Galanin_pre.
DR   InterPro; IPR013068; GMAP.
DR   PANTHER; PTHR16839; PTHR16839; 1.
DR   Pfam; PF01296; Galanin; 1.
DR   Pfam; PF06540; GMAP; 1.
DR   PRINTS; PR00273; GALANIN.
DR   SMART; SM00071; Galanin; 1.
DR   PROSITE; PS00861; GALANIN; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW   Hormone; Neuropeptide; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..30
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000010460"
FT   PEPTIDE         33..61
FT                   /note="Galanin"
FT                   /id="PRO_0000010461"
FT   PEPTIDE         65..117
FT                   /note="Galanin message-associated peptide"
FT                   /id="PRO_0000010462"
FT   MOD_RES         61
FT                   /note="Threonine amide"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         46
FT                   /note="H -> RRIDHLLMIKEMPIARGEEAPGAY (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11108248"
FT                   /id="VSP_001597"
SQ   SEQUENCE   117 AA;  12912 MW;  8A4795C460CD4FEF CRC64;
     MQRCAGFLFL SLILCAALSE TFGLVLSAKE KRGWTLNSAG YLLGPHAVDN HRSFNDKHGF
     TGKREIQPEE DIKAGNIGRP LADENIVRTV VEFLTYLHLK EAGALDNLPS PEETNES