GALA_MOUSE
ID GALA_MOUSE Reviewed; 124 AA.
AC P47212;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Galanin peptides;
DE Contains:
DE RecName: Full=Galanin;
DE Contains:
DE RecName: Full=Galanin message-associated peptide;
DE Short=GMAP;
DE Flags: Precursor;
GN Name=Gal; Synonyms=Galn;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129; TISSUE=Liver;
RX PubMed=8982069; DOI=10.1016/s0378-1119(96)00477-5;
RA Kofler B., Liu M.L., Jacoby A.S., Shine J., Iismaa T.P.;
RT "Molecular cloning and characterisation of the mouse preprogalanin gene.";
RL Gene 182:71-75(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 26-124.
RC TISSUE=Hypothalamus;
RX PubMed=8614559; DOI=10.1016/0304-3940(95)12094-k;
RA Lundkvist J., Land T., Kahl U., Bedecs K., Bartfai T.;
RT "cDNA sequence, ligand binding, and regulation of galanin/GMAP in mouse
RT brain.";
RL Neurosci. Lett. 200:121-124(1995).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=33712461; DOI=10.1126/sciadv.abe4983;
RA Brodie-Kommit J., Clark B.S., Shi Q., Shiau F., Kim D.W., Langel J.,
RA Sheely C., Ruzycki P.A., Fries M., Javed A., Cayouette M., Schmidt T.,
RA Badea T., Glaser T., Zhao H., Singer J., Blackshaw S., Hattar S.;
RT "Atoh7-independent specification of retinal ganglion cell identity.";
RL Sci. Adv. 7:0-0(2021).
CC -!- FUNCTION: Endocrine hormone of the central and peripheral nervous
CC systems that binds and activates the G protein-coupled receptors GALR1,
CC GALR2, and GALR3 (By similarity). This small neuropeptide may regulate
CC diverse physiologic functions including contraction of smooth muscle of
CC the gastrointestinal and genitourinary tract, growth hormone and
CC insulin release and adrenal secretion (By similarity).
CC {ECO:0000250|UniProtKB:P22466}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P22466}.
CC -!- TISSUE SPECIFICITY: Expressed in retinal progenitor cells and retinal
CC ganglion cells (at protein level). {ECO:0000269|PubMed:33712461}.
CC -!- SIMILARITY: Belongs to the galanin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L38580; AAB41545.1; -; Genomic_DNA.
DR EMBL; L38576; AAB41545.1; JOINED; Genomic_DNA.
DR EMBL; L38577; AAB41545.1; JOINED; Genomic_DNA.
DR EMBL; L38578; AAB41545.1; JOINED; Genomic_DNA.
DR EMBL; L38579; AAB41545.1; JOINED; Genomic_DNA.
DR EMBL; BC044055; AAH44055.1; -; mRNA.
DR EMBL; Z23069; CAA80610.1; -; mRNA.
DR CCDS; CCDS29396.1; -.
DR PIR; JC5480; JC5480.
DR PIR; S34301; S34301.
DR RefSeq; NP_034383.1; NM_010253.4.
DR AlphaFoldDB; P47212; -.
DR BMRB; P47212; -.
DR STRING; 10090.ENSMUSP00000025842; -.
DR iPTMnet; P47212; -.
DR PhosphoSitePlus; P47212; -.
DR PaxDb; P47212; -.
DR PRIDE; P47212; -.
DR ProteomicsDB; 271658; -.
DR ABCD; P47212; 16 sequenced antibodies.
DR Antibodypedia; 30599; 367 antibodies from 37 providers.
DR Ensembl; ENSMUST00000237521; ENSMUSP00000157515; ENSMUSG00000024907.
DR GeneID; 14419; -.
DR KEGG; mmu:14419; -.
DR UCSC; uc008fwj.1; mouse.
DR CTD; 51083; -.
DR MGI; MGI:95637; Gal.
DR VEuPathDB; HostDB:ENSMUSG00000024907; -.
DR eggNOG; ENOG502RZ1E; Eukaryota.
DR GeneTree; ENSGT00390000009663; -.
DR HOGENOM; CLU_166244_0_0_1; -.
DR InParanoid; P47212; -.
DR OMA; PEDDMKP; -.
DR OrthoDB; 1518030at2759; -.
DR PhylomeDB; P47212; -.
DR TreeFam; TF335850; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 14419; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Ggta1; mouse.
DR PRO; PR:P47212; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; P47212; protein.
DR Bgee; ENSMUSG00000024907; Expressed in medial preoptic region and 145 other tissues.
DR ExpressionAtlas; P47212; baseline and differential.
DR Genevisible; P47212; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR GO; GO:0030141; C:secretory granule; ISO:MGI.
DR GO; GO:0004966; F:galanin receptor activity; ISS:UniProtKB.
DR GO; GO:0031763; F:galanin receptor binding; IBA:GO_Central.
DR GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR GO; GO:0031764; F:type 1 galanin receptor binding; ISS:UniProtKB.
DR GO; GO:0031765; F:type 2 galanin receptor binding; ISS:UniProtKB.
DR GO; GO:0031766; F:type 3 galanin receptor binding; ISS:UniProtKB.
DR GO; GO:0019933; P:cAMP-mediated signaling; ISO:MGI.
DR GO; GO:0007631; P:feeding behavior; ISO:MGI.
DR GO; GO:0006954; P:inflammatory response; ISO:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0050672; P:negative regulation of lymphocyte proliferation; ISO:MGI.
DR GO; GO:0007399; P:nervous system development; IMP:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IMP:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:0051464; P:positive regulation of cortisol secretion; ISO:MGI.
DR GO; GO:1902608; P:positive regulation of large conductance calcium-activated potassium channel activity; ISO:MGI.
DR GO; GO:0051795; P:positive regulation of timing of catagen; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0010737; P:protein kinase A signaling; ISO:MGI.
DR GO; GO:0031943; P:regulation of glucocorticoid metabolic process; ISO:MGI.
DR InterPro; IPR008174; Galanin.
DR InterPro; IPR008175; Galanin_pre.
DR InterPro; IPR013068; GMAP.
DR PANTHER; PTHR16839; PTHR16839; 1.
DR Pfam; PF01296; Galanin; 1.
DR Pfam; PF06540; GMAP; 1.
DR PRINTS; PR00273; GALANIN.
DR SMART; SM00071; Galanin; 1.
DR PROSITE; PS00861; GALANIN; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW Phosphoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..30
FT /evidence="ECO:0000250"
FT /id="PRO_0000010451"
FT PEPTIDE 33..61
FT /note="Galanin"
FT /evidence="ECO:0000250"
FT /id="PRO_0000010452"
FT PEPTIDE 65..124
FT /note="Galanin message-associated peptide"
FT /evidence="ECO:0000250"
FT /id="PRO_0000010453"
FT MOD_RES 61
FT /note="Threonine amide"
FT /evidence="ECO:0000250"
FT MOD_RES 117
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P22466"
FT MOD_RES 118
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P22466"
SQ SEQUENCE 124 AA; 13471 MW; B49B03B60FACEFD7 CRC64;
MARGSVILLG WLLLVVTLSA TLGLGMPAKE KRGWTLNSAG YLLGPHAIDN HRSFSDKHGL
TGKRELQLEV EERRPGSVDV PLPESNIVRT IMEFLSFLHL KEAGALDSLP GIPLATSSED
LEKS
