GALA_PIG
ID GALA_PIG Reviewed; 123 AA.
AC P07480; Q9TRN1;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Galanin peptides;
DE Contains:
DE RecName: Full=Galanin;
DE Contains:
DE RecName: Full=Galanin message-associated peptide;
DE Short=GMAP;
DE Flags: Precursor;
GN Name=GAL; Synonyms=GALN;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2428032; DOI=10.1073/pnas.83.17.6287;
RA Rokaeus A., Brownstein M.J.;
RT "Construction of a porcine adrenal medullary cDNA library and nucleotide
RT sequence analysis of two clones encoding a galanin precursor.";
RL Proc. Natl. Acad. Sci. U.S.A. 83:6287-6291(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Adrenal medulla;
RX PubMed=1718731; DOI=10.1210/endo-129-5-2693;
RA Bersani M., Thim L., Rasmussen T.N., Holst J.J.;
RT "Galanin and galanin extended at the N-terminus with seven and nine amino
RT acids are produced in and secreted from the porcine adrenal medulla in
RT almost equal amounts.";
RL Endocrinology 129:2693-2698(1991).
RN [3]
RP PROTEIN SEQUENCE OF 33-61, FUNCTION, AMIDATION AT ALA-61, AND SUBCELLULAR
RP LOCATION.
RC TISSUE=Intestine;
RX PubMed=6197320; DOI=10.1016/0014-5793(83)80033-7;
RA Tatemoto K., Rokaeus A., Joernvall H., McDonald T.J., Mutt V.;
RT "Galanin - a novel biologically active peptide from porcine intestine.";
RL FEBS Lett. 164:124-128(1983).
RN [4]
RP PROTEIN SEQUENCE OF 33-61, FUNCTION, AND SUBCELLULAR LOCATION.
RC TISSUE=Gastric corpus;
RX PubMed=1381832; DOI=10.1016/0196-9781(92)90094-j;
RA McDonald T.J., Krantis A., Clarke M., Mutt V., Joernvall H.;
RT "Characterization of porcine gastric galanin.";
RL Peptides 13:589-593(1992).
CC -!- FUNCTION: Endocrine hormone of the central and peripheral nervous
CC systems that binds and activates the G protein-coupled receptors GALR1,
CC GALR2, and GALR3. This small neuropeptide may regulate diverse
CC physiologic functions including contraction of smooth muscle of the
CC gastrointestinal and genitourinary tract, growth hormone and insulin
CC release and adrenal secretion. {ECO:0000269|PubMed:1381832,
CC ECO:0000269|PubMed:6197320}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1381832,
CC ECO:0000269|PubMed:6197320}.
CC -!- SIMILARITY: Belongs to the galanin family. {ECO:0000305}.
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DR EMBL; M13826; AAA31097.1; -; mRNA.
DR PIR; A23540; RHPGN.
DR RefSeq; NP_999399.1; NM_214234.1.
DR AlphaFoldDB; P07480; -.
DR BioGRID; 1149592; 1.
DR STRING; 9823.ENSSSCP00000013698; -.
DR PaxDb; P07480; -.
DR Ensembl; ENSSSCT00035068053; ENSSSCP00035027569; ENSSSCG00035051075.
DR GeneID; 397465; -.
DR KEGG; ssc:397465; -.
DR CTD; 51083; -.
DR eggNOG; ENOG502RZ1E; Eukaryota.
DR HOGENOM; CLU_166244_0_0_1; -.
DR InParanoid; P07480; -.
DR OrthoDB; 1518030at2759; -.
DR TreeFam; TF335850; -.
DR Reactome; R-SSC-375276; Peptide ligand-binding receptors.
DR Reactome; R-SSC-418594; G alpha (i) signalling events.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR Genevisible; P07480; SS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR GO; GO:0004966; F:galanin receptor activity; ISS:UniProtKB.
DR GO; GO:0031763; F:galanin receptor binding; IBA:GO_Central.
DR GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR GO; GO:0031764; F:type 1 galanin receptor binding; ISS:UniProtKB.
DR GO; GO:0031765; F:type 2 galanin receptor binding; ISS:UniProtKB.
DR GO; GO:0031766; F:type 3 galanin receptor binding; ISS:UniProtKB.
DR GO; GO:0090275; P:negative regulation of somatostatin secretion; IMP:AgBase.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0090274; P:positive regulation of somatostatin secretion; IMP:AgBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR InterPro; IPR008174; Galanin.
DR InterPro; IPR008175; Galanin_pre.
DR InterPro; IPR013068; GMAP.
DR PANTHER; PTHR16839; PTHR16839; 1.
DR Pfam; PF01296; Galanin; 1.
DR Pfam; PF06540; GMAP; 1.
DR PRINTS; PR00273; GALANIN.
DR SMART; SM00071; Galanin; 1.
DR PROSITE; PS00861; GALANIN; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Hormone; Neuropeptide; Phosphoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..30
FT /id="PRO_0000010454"
FT PEPTIDE 33..61
FT /note="Galanin"
FT /id="PRO_0000010455"
FT PEPTIDE 65..123
FT /note="Galanin message-associated peptide"
FT /id="PRO_0000010456"
FT MOD_RES 61
FT /note="Alanine amide"
FT /evidence="ECO:0000269|PubMed:6197320"
FT MOD_RES 116
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P22466"
FT MOD_RES 117
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P22466"
SQ SEQUENCE 123 AA; 13081 MW; 486EF70C04F9F24C CRC64;
MPRGCALLLA SLLLASALSA TLGLGSPVKE KRGWTLNSAG YLLGPHAIDN HRSFHDKYGL
AGKRELEPED EARPGGFDRL QSEDKAIRTI MEFLAFLHLK EAGALGRLPG LPSAASSEDA
GQS
