GALA_RAT
ID GALA_RAT Reviewed; 124 AA.
AC P10683;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Galanin peptides;
DE Contains:
DE RecName: Full=Galanin;
DE Contains:
DE RecName: Full=Galanin message-associated peptide;
DE Short=GMAP;
DE Flags: Precursor;
GN Name=Gal; Synonyms=Galn;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT THR-61.
RX PubMed=2448788; DOI=10.1073/pnas.85.4.1065;
RA Kaplan L.M., Spindel E.R., Isselbacher K.J., Chin W.W.;
RT "Tissue-specific expression of the rat galanin gene.";
RL Proc. Natl. Acad. Sci. U.S.A. 85:1065-1069(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2445750; DOI=10.1016/s0021-9258(18)45446-4;
RA Vrontakis M.E., Peden L.M., Duckworth M.L., Friesen H.G.;
RT "Isolation and characterization of a complementary DNA (galanin) clone from
RT estrogen-induced pituitary tumor messenger RNA.";
RL J. Biol. Chem. 262:16755-16758(1987).
CC -!- FUNCTION: Endocrine hormone of the central and peripheral nervous
CC systems that binds and activates the G protein-coupled receptors GALR1,
CC GALR2, and GALR3. This small neuropeptide may regulate diverse
CC physiologic functions including contraction of smooth muscle of the
CC gastrointestinal and genitourinary tract, growth hormone and insulin
CC release and adrenal secretion. {ECO:0000250|UniProtKB:P07480,
CC ECO:0000250|UniProtKB:P22466}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P07480,
CC ECO:0000250|UniProtKB:P22466}.
CC -!- SIMILARITY: Belongs to the galanin family. {ECO:0000305}.
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DR EMBL; J03624; AAA41186.1; -; mRNA.
DR EMBL; M18102; AAA41187.1; -; mRNA.
DR PIR; A28463; RHRTN.
DR RefSeq; NP_150240.1; NM_033237.1.
DR AlphaFoldDB; P10683; -.
DR BMRB; P10683; -.
DR STRING; 10116.ENSRNOP00000020425; -.
DR BindingDB; P10683; -.
DR iPTMnet; P10683; -.
DR PhosphoSitePlus; P10683; -.
DR PaxDb; P10683; -.
DR Ensembl; ENSRNOT00000020425; ENSRNOP00000020425; ENSRNOG00000015156.
DR GeneID; 29141; -.
DR KEGG; rno:29141; -.
DR UCSC; RGD:61954; rat.
DR CTD; 51083; -.
DR RGD; 61954; Gal.
DR eggNOG; ENOG502RZ1E; Eukaryota.
DR GeneTree; ENSGT00390000009663; -.
DR HOGENOM; CLU_166244_0_0_1; -.
DR InParanoid; P10683; -.
DR OMA; PEDDMKP; -.
DR OrthoDB; 1518030at2759; -.
DR PhylomeDB; P10683; -.
DR TreeFam; TF335850; -.
DR Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:P10683; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000015156; Expressed in colon and 11 other tissues.
DR Genevisible; P10683; RN.
DR GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0005794; C:Golgi apparatus; IDA:RGD.
DR GO; GO:0043025; C:neuronal cell body; ISO:RGD.
DR GO; GO:0030141; C:secretory granule; IDA:RGD.
DR GO; GO:0001664; F:G protein-coupled receptor binding; TAS:RGD.
DR GO; GO:0004966; F:galanin receptor activity; ISS:UniProtKB.
DR GO; GO:0031763; F:galanin receptor binding; IBA:GO_Central.
DR GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR GO; GO:0031764; F:type 1 galanin receptor binding; ISS:UniProtKB.
DR GO; GO:0031765; F:type 2 galanin receptor binding; ISS:UniProtKB.
DR GO; GO:0031766; F:type 3 galanin receptor binding; ISS:UniProtKB.
DR GO; GO:0019933; P:cAMP-mediated signaling; ISO:RGD.
DR GO; GO:0007631; P:feeding behavior; IDA:RGD.
DR GO; GO:0006954; P:inflammatory response; IDA:RGD.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:RGD.
DR GO; GO:0050672; P:negative regulation of lymphocyte proliferation; IDA:RGD.
DR GO; GO:0007399; P:nervous system development; ISO:RGD.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISO:RGD.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IDA:RGD.
DR GO; GO:0051464; P:positive regulation of cortisol secretion; ISO:RGD.
DR GO; GO:1902608; P:positive regulation of large conductance calcium-activated potassium channel activity; ISO:RGD.
DR GO; GO:0051795; P:positive regulation of timing of catagen; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0010737; P:protein kinase A signaling; ISO:RGD.
DR GO; GO:0031943; P:regulation of glucocorticoid metabolic process; IMP:RGD.
DR GO; GO:0050776; P:regulation of immune response; TAS:RGD.
DR GO; GO:0043627; P:response to estrogen; IEP:RGD.
DR GO; GO:0035902; P:response to immobilization stress; IEP:RGD.
DR GO; GO:0032868; P:response to insulin; IEP:RGD.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR InterPro; IPR008174; Galanin.
DR InterPro; IPR008175; Galanin_pre.
DR InterPro; IPR013068; GMAP.
DR PANTHER; PTHR16839; PTHR16839; 1.
DR Pfam; PF01296; Galanin; 1.
DR Pfam; PF06540; GMAP; 1.
DR PRINTS; PR00273; GALANIN.
DR SMART; SM00071; Galanin; 1.
DR PROSITE; PS00861; GALANIN; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW Phosphoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..30
FT /id="PRO_0000010457"
FT PEPTIDE 33..61
FT /note="Galanin"
FT /id="PRO_0000010458"
FT PEPTIDE 65..124
FT /note="Galanin message-associated peptide"
FT /id="PRO_0000010459"
FT MOD_RES 61
FT /note="Threonine amide"
FT /evidence="ECO:0000269|PubMed:2448788"
FT MOD_RES 117
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P22466"
FT MOD_RES 118
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P22466"
SQ SEQUENCE 124 AA; 13328 MW; E45AB91A7E83B989 CRC64;
MARGSVILLA WLLLVATLSA TLGLGMPTKE KRGWTLNSAG YLLGPHAIDN HRSFSDKHGL
TGKRELPLEV EEGRLGSVAV PLPESNIVRT IMEFLSFLHL KEAGALDSLP GIPLATSSED
LEQS
