GALD1_MOUSE
ID GALD1_MOUSE Reviewed; 220 AA.
AC Q8BFQ8; Q8C2Q9;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Glutamine amidotransferase-like class 1 domain-containing protein 1 {ECO:0000305};
DE AltName: Full=Parkinson disease 7 domain-containing protein 1 {ECO:0000312|MGI:MGI:2387178};
DE Flags: Precursor;
GN Name=Gatd1 {ECO:0000250|UniProtKB:Q8NB37};
GN Synonyms=Pddc1 {ECO:0000312|MGI:MGI:2387178};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Cerebellum, Eye, Head, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the peptidase C56 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC40181.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK081187; BAC38160.1; -; mRNA.
DR EMBL; AK084273; BAC39152.1; -; mRNA.
DR EMBL; AK088159; BAC40181.1; ALT_FRAME; mRNA.
DR EMBL; AK140975; BAE24535.1; -; mRNA.
DR EMBL; BC023835; AAH23835.1; -; mRNA.
DR CCDS; CCDS52444.1; -.
DR RefSeq; NP_742114.3; NM_172116.4.
DR AlphaFoldDB; Q8BFQ8; -.
DR SMR; Q8BFQ8; -.
DR BioGRID; 229419; 1.
DR STRING; 10090.ENSMUSP00000101630; -.
DR GlyGen; Q8BFQ8; 1 site.
DR PhosphoSitePlus; Q8BFQ8; -.
DR SwissPalm; Q8BFQ8; -.
DR UCD-2DPAGE; Q8BFQ8; -.
DR EPD; Q8BFQ8; -.
DR jPOST; Q8BFQ8; -.
DR MaxQB; Q8BFQ8; -.
DR PaxDb; Q8BFQ8; -.
DR PeptideAtlas; Q8BFQ8; -.
DR PRIDE; Q8BFQ8; -.
DR ProteomicsDB; 273412; -.
DR Antibodypedia; 50448; 19 antibodies from 9 providers.
DR DNASU; 213350; -.
DR Ensembl; ENSMUST00000106008; ENSMUSP00000101630; ENSMUSG00000051007.
DR GeneID; 213350; -.
DR KEGG; mmu:213350; -.
DR UCSC; uc012fwy.1; mouse.
DR CTD; 347862; -.
DR MGI; MGI:2387178; Gatd1.
DR VEuPathDB; HostDB:ENSMUSG00000051007; -.
DR eggNOG; ENOG502QS6W; Eukaryota.
DR GeneTree; ENSGT00390000010778; -.
DR HOGENOM; CLU_098485_0_0_1; -.
DR InParanoid; Q8BFQ8; -.
DR OMA; DCPGAPN; -.
DR OrthoDB; 1305649at2759; -.
DR PhylomeDB; Q8BFQ8; -.
DR TreeFam; TF328533; -.
DR BioGRID-ORCS; 213350; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Gatd1; mouse.
DR PRO; PR:Q8BFQ8; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BFQ8; protein.
DR Bgee; ENSMUSG00000051007; Expressed in yolk sac and 160 other tissues.
DR Genevisible; Q8BFQ8; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019172; F:glyoxalase III activity; IBA:GO_Central.
DR GO; GO:0019243; P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IBA:GO_Central.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR SUPFAM; SSF52317; SSF52317; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..220
FT /note="Glutamine amidotransferase-like class 1 domain-
FT containing protein 1"
FT /id="PRO_0000305095"
FT CARBOHYD 203
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 9
FT /note="R -> G (in Ref. 1; BAC40181)"
FT /evidence="ECO:0000305"
FT CONFLICT 22
FT /note="G -> D (in Ref. 1; BAC40181)"
FT /evidence="ECO:0000305"
FT CONFLICT 141
FT /note="W -> R (in Ref. 1; BAC40181)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 220 AA; 23277 MW; FB0615AF7204CB23 CRC64;
MASERLPSRP ACLLVASGAS EGVSAQSFVH CFTLASAAFN LQVATPGGKA IDFVDVTESN
ARWVQDFRLK AYASPAKLES IDGARYHALL IPSCPGALTD LASSGSLARI LQHFRSESKP
ICAIGHGVAA LCCATNEDRS WVFQGYSLTG PSVYELIRAP GFARLPLIVE DFVKDSGAGF
SASEPDAVHV VLDRHLVTGQ NANSTVPAVQ NLLFLCGSRK
