ID   GALF_KLEPN              Reviewed;         298 AA.
AC   Q48447;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase;
DE            EC=2.7.7.9;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase;
DE   AltName: Full=UDP-glucose pyrophosphorylase;
DE            Short=UDPGP;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase;
GN   Name=galF;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Chedid;
RX   PubMed=7896702; DOI=10.1128/jb.177.7.1788-1796.1995;
RA   Arakawa Y., Wacharotayankun R., Nagatsuka T., Ito H., Kato N., Ohta M.;
RT   "Genomic organization of the Klebsiella pneumoniae cps region responsible
RT   for serotype K2 capsular polysaccharide synthesis in the virulent strain
RT   Chedid.";
RL   J. Bacteriol. 177:1788-1796(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC         alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:58885; EC=2.7.7.9;
CC   -!- PATHWAY: Carbohydrate metabolism; nucleotide-sugar metabolism.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
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DR   EMBL; D21242; BAA04772.1; -; Genomic_DNA.
DR   PIR; A56146; A56146.
DR   RefSeq; WP_001055540.1; NZ_CP042312.1.
DR   AlphaFoldDB; Q48447; -.
DR   SMR; Q48447; -.
DR   PRIDE; Q48447; -.
DR   UniPathway; UPA00215; -.
DR   UniPathway; UPA00934; -.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:InterPro.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   CDD; cd02541; UGPase_prokaryotic; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005774; GalF.
DR   InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR43197; PTHR43197; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR01105; galF; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Lipopolysaccharide biosynthesis;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..298
FT                   /note="UTP--glucose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000201348"
SQ   SEQUENCE   298 AA;  32778 MW;  C4E5DD3C3E12CE44 CRC64;
     MNMANLKAVI PVAGLGMHML PATKAIPKEM LPIVDKPMIQ YIVDEIVAAG IKEIVLVTHS
     SKNAVENHFD TSYELEALLE QRVKRQLLAE VQAICPPGVT IMNVRQAQPL GLGHSILCAR
     PVVGDNPFVV VLPDIILDGG TADPLRYNLA AMIARFNETG RSQVLAKRMP GDLSEYSVIQ
     TKEPMVAEGQ VARIVEFIEK PDEPQTLDSD LMAVGRYVLS ADIWAELERT EPGAWGRIQL
     TDAIAELAKK QSVDAMLMTG ESYDCGKKMG YMQAFVTYGM RNLKEGAKFR ESIKKLLA