ID   GALM_LACHE              Reviewed;         129 AA.
AC   Q00053;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Aldose 1-epimerase;
DE            EC=5.1.3.3;
DE   AltName: Full=Galactose mutarotase;
DE   AltName: Full=Type-1 mutarotase;
DE   Flags: Fragment;
GN   Name=galM;
OS   Lactobacillus helveticus (Lactobacillus suntoryeus).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15009 / DSM 20075 / BCRC 12936 / JCM 1120 / NBRC 15019 / NCIMB
RC   11971 / NRRL B-4526 / Lh12;
RX   PubMed=2066342; DOI=10.1128/jb.173.14.4464-4473.1991;
RA   Mollet B., Pilloud N.;
RT   "Galactose utilization in Lactobacillus helveticus: isolation and
RT   characterization of the galactokinase (galK) and galactose-1-phosphate
RT   uridyl transferase (galT) genes.";
RL   J. Bacteriol. 173:4464-4473(1991).
CC   -!- FUNCTION: Mutarotase converts alpha-aldose to the beta-anomer. It is
CC       active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and
CC       lactose (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose = beta-D-glucose; Xref=Rhea:RHEA:10264,
CC         ChEBI:CHEBI:15903, ChEBI:CHEBI:17925; EC=5.1.3.3;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10126};
CC   -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC   -!- SIMILARITY: Belongs to the aldose epimerase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X57248; CAA40527.1; -; Genomic_DNA.
DR   PIR; C47032; C47032.
DR   AlphaFoldDB; Q00053; -.
DR   SMR; Q00053; -.
DR   STRING; 326425.lhe_1408; -.
DR   eggNOG; COG2017; Bacteria.
DR   UniPathway; UPA00242; -.
DR   GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.70.98.10; -; 1.
DR   InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR014718; GH-type_carb-bd.
DR   Pfam; PF01263; Aldose_epim; 1.
DR   SUPFAM; SSF74650; SSF74650; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Isomerase.
FT   CHAIN           1..>129
FT                   /note="Aldose 1-epimerase"
FT                   /id="PRO_0000197446"
FT   NON_TER         129
SQ   SEQUENCE   129 AA;  14441 MW;  506045CEE52E2A42 CRC64;
     MKTSFNKYGR KDGKDLCEIV LENDHGMIVK VLNYGATLEK VLLNDENMIL SLNSPADYSQ
     ERNYLGGTVG RIAGRVRKGQ WRHGLETHQL PINDGENHIH GGIGTDTEVW DFKPSCSENS
     ARVDLTLLD