GALP_ECOL6
ID GALP_ECOL6 Reviewed; 464 AA.
AC P0AEP2; P37021;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Galactose-proton symporter;
DE AltName: Full=Galactose transporter;
GN Name=galP; OrderedLocusNames=c3529;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Uptake of galactose across the boundary membrane with the
CC concomitant transport of protons into the cell (symport system).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN81977.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE014075; AAN81977.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_001112301.1; NC_004431.1.
DR AlphaFoldDB; P0AEP2; -.
DR SMR; P0AEP2; -.
DR STRING; 199310.c3529; -.
DR PRIDE; P0AEP2; -.
DR EnsemblBacteria; AAN81977; AAN81977; c3529.
DR GeneID; 67415165; -.
DR KEGG; ecc:c3529; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_001265_30_5_6; -.
DR OMA; SCHEQEM; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Sugar transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..464
FT /note="Galactose-proton symporter"
FT /id="PRO_0000050293"
FT TOPO_DOM 1..15
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..56
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..112
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..171
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..290
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 312..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 343..351
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 373..394
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 416
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 438..464
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 464 AA; 50983 MW; 07E08935BD8E3F8E CRC64;
MPDAKKQGRS NKAMTFFVCF LAALAGLLFG LDIGVIAGAL PFIADEFQIT SHTQEWVVSS
MMFGAAVGAV GSGWLSFKLG RKKSLMIGAI LFVAGSLFSA AAPNVEVLIL SRVLLGLAVG
VASYTAPLYL SEIAPEKIRG SMISMYQLMI TIGILGAYLS DTAFSYTGAW RWMLGVIIIP
AILLLIGVFF LPDSPRWFAA KRRFVDAERV LLRLRDTSAE AKRELDEIRE SLQVKQSGWA
LFKENSNFRR AVFLGVLLQV MQQFTGMNVI MYYAPKIFEL AGYTNTTEQM WGTVIVGLTN
VLATFIAIGL VDRWGRKPTL TLGFLVMAAG MGVLGTMMHI GIHSPSAQYF AIAMLLMFIV
GFAMSAGPLI WVLCSEIQPL KGRDFGITCS TATNWIANMI VGATFLTMLN TLGNANTFWV
YAALNVLFIL LTLWLVPETK HVSLEHIERN LMKGRKLREI GAHD
