ID   GALP_MACNE              Reviewed;         115 AA.
AC   Q8SQD7; A5GXX3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Galanin-like peptide;
DE   Flags: Precursor;
GN   Name=GALP;
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX   PubMed=11861493; DOI=10.1210/endo.143.3.8661;
RA   Cunningham M.J., Scarlett J.M., Steiner R.A.;
RT   "Cloning and distribution of galanin-like peptide mRNA in the hypothalamus
RT   and pituitary of the macaque.";
RL   Endocrinology 143:755-763(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA   Kofler B., Voglas E., Santic R.;
RT   "Alarin a novel neuropeptide derived by differential splicing of the
RT   galanin-like peptide gene.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: [Isoform 1]: Hypothalamic neuropeptide which binds to the G-
CC       protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in
CC       a large number of putative physiological functions in CNS homeostatic
CC       processes, including the regulation of gonadotropin-releasing hormone
CC       secretion (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: [Isoform 2]: Exhibits potent and dose-dependent
CC       vasoconstrictor and anti-edema activity in the cutaneous
CC       microvasculature, a physiologic effects which does not appear to be
CC       mediated via GALR1 or GALR2. Exhibits antimicrobial activity against
CC       Gram-negative bacterias, inducing bacterial membrane blebbing (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8SQD7-1; Sequence=Displayed;
CC       Name=2; Synonyms=Alarin;
CC         IsoId=Q8SQD7-2; Sequence=VSP_030461;
CC   -!- TISSUE SPECIFICITY: Hypothalamus and pituitary gland.
CC       {ECO:0000269|PubMed:11861493}.
CC   -!- MISCELLANEOUS: [Isoform 2]: Cleavage of the signal peptide generates a
CC       peptide of 25 amino acids, termed alarin because of the N-terminal
CC       alanine and the C-terminal serine. Vasoactive peptide. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the galanin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF459739; AAL79533.1; -; mRNA.
DR   EMBL; DQ153216; ABA38685.1; -; mRNA.
DR   RefSeq; XP_011750255.1; XM_011751953.1. [Q8SQD7-1]
DR   AlphaFoldDB; Q8SQD7; -.
DR   STRING; 9545.ENSMNEP00000002747; -.
DR   Ensembl; ENSMNET00000013894; ENSMNEP00000002747; ENSMNEG00000012763. [Q8SQD7-1]
DR   Ensembl; ENSMNET00000013910; ENSMNEP00000002752; ENSMNEG00000012763. [Q8SQD7-2]
DR   GeneID; 105488137; -.
DR   CTD; 85569; -.
DR   GeneTree; ENSGT00390000016349; -.
DR   OMA; PQMSDQD; -.
DR   OrthoDB; 1502468at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042595; P:behavioral response to starvation; IEA:Ensembl.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0032098; P:regulation of appetite; IEA:Ensembl.
DR   InterPro; IPR008174; Galanin.
DR   InterPro; IPR039244; GALP.
DR   PANTHER; PTHR20950; PTHR20950; 1.
DR   Pfam; PF01296; Galanin; 1.
DR   PROSITE; PS00861; GALANIN; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Antibiotic; Antimicrobial;
KW   Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..83
FT                   /note="Galanin-like peptide"
FT                   /id="PRO_0000315041"
FT   PROPEP          86..115
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000315042"
FT   VAR_SEQ         29..114
FT                   /note="GRGGWTLNSAGYLLGPVLHLPQMGDQDRKRETALEILDLWKAIDGLPYSHPL
FT                   QPSKRNVMEAFAKPEIGDLDVLSKKIPKEEDVLK -> SSTFPKWVTKTGRGRQPLR
FT                   (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_030461"
SQ   SEQUENCE   115 AA;  12528 MW;  5F3B3A494FED5E59 CRC64;
     MAPSVPLVLL LVLLLSLAET PASAPAHQGR GGWTLNSAGY LLGPVLHLPQ MGDQDRKRET
     ALEILDLWKA IDGLPYSHPL QPSKRNVMEA FAKPEIGDLD VLSKKIPKEE DVLKS