GALP_MOUSE
ID GALP_MOUSE Reviewed; 117 AA.
AC Q810H5; A5GXX4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Galanin-like peptide;
DE Flags: Precursor;
GN Name=Galp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND FUNCTION.
RC STRAIN=BALB/cJ;
RX PubMed=12746327; DOI=10.1210/en.2002-221113;
RA Kumano S., Matsumoto H., Takatsu Y., Noguchi J., Kitada C., Ohtaki T.;
RT "Changes in hypothalamic expression levels of galanin-like peptide in rat
RT and mouse models support that it is a leptin-target peptide.";
RL Endocrinology 144:2634-2643(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, AND TISSUE SPECIFICITY
RP (ISOFORM 2).
RX PubMed=17535903; DOI=10.1073/pnas.0608585104;
RA Santic R., Schmidhuber S.M., Lang R., Rauch I., Voglas E., Eberhard N.,
RA Bauer J.W., Brain S.D., Kofler B.;
RT "Alarin is a vasoactive peptide.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:10217-10222(2007).
CC -!- FUNCTION: [Isoform 1]: Hypothalamic neuropeptide which binds to the G-
CC protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in
CC a large number of putative physiological functions in CNS homeostatic
CC processes, including the regulation of gonadotropin-releasing hormone
CC secretion.
CC -!- FUNCTION: [Isoform 2]: Exhibits antimicrobial activity against Gram-
CC negative bacterias, inducing bacterial membrane blebbing (By
CC similarity). Exhibits potent and dose-dependent vasoconstrictor and
CC anti-edema activity in the cutaneous microvasculature, a physiologic
CC effects which does not appear to be mediated via GALR1 or GALR2.
CC {ECO:0000250, ECO:0000269|PubMed:12746327,
CC ECO:0000269|PubMed:17535903}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q810H5-1; Sequence=Displayed;
CC Name=2; Synonyms=Alarin;
CC IsoId=Q810H5-2; Sequence=VSP_030462;
CC -!- TISSUE SPECIFICITY: Isoform 2 is found in brain, thymus and skin.
CC Isoform 2 is found in the skin, in pericytes covering microvascular
CC arterioles and venules on their abluminal surfaces. In larger vessels,
CC isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is
CC not detected in endothelial cells.
CC -!- MISCELLANEOUS: [Isoform 2]: Cleavage of the signal peptide generates a
CC peptide of 25 amino acids, termed alarin because of the N-terminal
CC alanine and the C-terminal serine. Vasoactive peptide. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the galanin family. {ECO:0000305}.
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DR EMBL; AY163546; AAO22485.1; -; mRNA.
DR EMBL; DQ155644; ABA39411.1; -; mRNA.
DR CCDS; CCDS20771.1; -. [Q810H5-1]
DR RefSeq; NP_821171.1; NM_178028.2. [Q810H5-1]
DR RefSeq; XP_006539852.1; XM_006539789.1.
DR AlphaFoldDB; Q810H5; -.
DR STRING; 10090.ENSMUSP00000037408; -.
DR PhosphoSitePlus; Q810H5; -.
DR PaxDb; Q810H5; -.
DR PRIDE; Q810H5; -.
DR Antibodypedia; 33185; 107 antibodies from 22 providers.
DR DNASU; 232836; -.
DR Ensembl; ENSMUST00000037553; ENSMUSP00000037408; ENSMUSG00000034660. [Q810H5-1]
DR GeneID; 232836; -.
DR KEGG; mmu:232836; -.
DR UCSC; uc009fax.1; mouse. [Q810H5-1]
DR CTD; 85569; -.
DR MGI; MGI:2663979; Galp.
DR VEuPathDB; HostDB:ENSMUSG00000034660; -.
DR eggNOG; ENOG502TI9H; Eukaryota.
DR GeneTree; ENSGT00390000016349; -.
DR HOGENOM; CLU_167264_0_0_1; -.
DR InParanoid; Q810H5; -.
DR OMA; PQMSDQD; -.
DR OrthoDB; 1502468at2759; -.
DR PhylomeDB; Q810H5; -.
DR TreeFam; TF339481; -.
DR BioGRID-ORCS; 232836; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Galp; mouse.
DR PRO; PR:Q810H5; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q810H5; protein.
DR Bgee; ENSMUSG00000034660; Expressed in testis and 3 other tissues.
DR ExpressionAtlas; Q810H5; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; TAS:MGI.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:0042595; P:behavioral response to starvation; IMP:MGI.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:MGI.
DR GO; GO:0035821; P:modulation of process of another organism; ISO:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0032098; P:regulation of appetite; IMP:MGI.
DR GO; GO:0032868; P:response to insulin; IEA:Ensembl.
DR InterPro; IPR008174; Galanin.
DR InterPro; IPR039244; GALP.
DR PANTHER; PTHR20950; PTHR20950; 1.
DR Pfam; PF01296; Galanin; 1.
DR PROSITE; PS00861; GALANIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Antibiotic; Antimicrobial;
KW Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..83
FT /note="Galanin-like peptide"
FT /id="PRO_0000316085"
FT PROPEP 86..117
FT /evidence="ECO:0000250"
FT /id="PRO_0000316086"
FT VAR_SEQ 29..117
FT /note="GRGGWTLNSAGYLLGPVLPVSSKADQGRKRDSALEILDLWKIIDGLPYSHSP
FT RMTKRTMGETFVKANTGDMHILDKNVPKEEATLDSES -> SSPFPPRPTRAGRETQLL
FT R (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17535903"
FT /id="VSP_030462"
SQ SEQUENCE 117 AA; 12773 MW; 558519C42811D58D CRC64;
MACSVHLVLF LTILLSLAET PESAPAHRGR GGWTLNSAGY LLGPVLPVSS KADQGRKRDS
ALEILDLWKI IDGLPYSHSP RMTKRTMGET FVKANTGDMH ILDKNVPKEE ATLDSES
