ID   GALP_PIG                Reviewed;         120 AA.
AC   Q9TT95;
DT   11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Galanin-like peptide;
DE   Flags: Precursor;
GN   Name=GALP;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 23-82, AND SYNTHESIS OF
RP   23-82.
RC   TISSUE=Hypothalamus;
RX   PubMed=10601261; DOI=10.1074/jbc.274.52.37041;
RA   Ohtaki T., Kumano S., Ishibashi Y., Ogi K., Matsui H., Harada M.,
RA   Kitada C., Kurokawa T., Onda H., Fujino M.;
RT   "Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from
RT   porcine hypothalamus.";
RL   J. Biol. Chem. 274:37041-37045(1999).
CC   -!- FUNCTION: Hypothalamic neuropeptide which binds to the G-protein-
CC       coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large
CC       number of putative physiological functions in CNS homeostatic
CC       processes, including the regulation of gonadotropin-releasing hormone
CC       secretion (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the galanin family. {ECO:0000305}.
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DR   EMBL; AF188490; AAF19722.1; -; mRNA.
DR   RefSeq; NP_998990.1; NM_213825.1.
DR   AlphaFoldDB; Q9TT95; -.
DR   STRING; 9823.ENSSSCP00000003598; -.
DR   PaxDb; Q9TT95; -.
DR   Ensembl; ENSSSCT00005073528; ENSSSCP00005046104; ENSSSCG00005045481.
DR   Ensembl; ENSSSCT00015027343; ENSSSCP00015010709; ENSSSCG00015020587.
DR   GeneID; 396772; -.
DR   KEGG; ssc:396772; -.
DR   CTD; 85569; -.
DR   eggNOG; ENOG502TI9H; Eukaryota.
DR   InParanoid; Q9TT95; -.
DR   OrthoDB; 1493889at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0042595; P:behavioral response to starvation; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR008174; Galanin.
DR   InterPro; IPR039244; GALP.
DR   PANTHER; PTHR20950; PTHR20950; 1.
DR   Pfam; PF01296; Galanin; 1.
DR   PROSITE; PS00861; GALANIN; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing; Hormone;
KW   Neuropeptide; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000269|PubMed:10601261"
FT   PEPTIDE         23..82
FT                   /note="Galanin-like peptide"
FT                   /id="PRO_0000010465"
FT   PROPEP          85..120
FT                   /id="PRO_0000010466"
SQ   SEQUENCE   120 AA;  12681 MW;  709F7D8F42149054 CRC64;
     MALTVPLIVL AVLLSLMESP ASAPVHRGRG GWTLNSAGYL LGPVLHPPSR AEGGGKGKTA
     LGILDLWKAI DGLPYPQSQL ASKRSLGETF AKPDSGVTFV GVPDVVPWKR IRPGTTRFQI