ID   GALP_RAT                Reviewed;         115 AA.
AC   Q9QXQ6;
DT   11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Galanin-like peptide;
DE   Flags: Precursor;
GN   Name=Galp;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10601261; DOI=10.1074/jbc.274.52.37041;
RA   Ohtaki T., Kumano S., Ishibashi Y., Ogi K., Matsui H., Harada M.,
RA   Kitada C., Kurokawa T., Onda H., Fujino M.;
RT   "Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from
RT   porcine hypothalamus.";
RL   J. Biol. Chem. 274:37041-37045(1999).
CC   -!- FUNCTION: Hypothalamic neuropeptide which binds to the G-protein-
CC       coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large
CC       number of putative physiological functions in CNS homeostatic
CC       processes, including the regulation of gonadotropin-releasing hormone
CC       secretion (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the galanin family. {ECO:0000305}.
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DR   EMBL; AF188491; AAF19723.1; -; mRNA.
DR   RefSeq; NP_072155.1; NM_022633.1.
DR   AlphaFoldDB; Q9QXQ6; -.
DR   STRING; 10116.ENSRNOP00000038710; -.
DR   PaxDb; Q9QXQ6; -.
DR   Ensembl; ENSRNOT00000034854; ENSRNOP00000038710; ENSRNOG00000022129.
DR   GeneID; 64568; -.
DR   KEGG; rno:64568; -.
DR   UCSC; RGD:620187; rat.
DR   CTD; 85569; -.
DR   RGD; 620187; Galp.
DR   eggNOG; ENOG502TI9H; Eukaryota.
DR   GeneTree; ENSGT00390000016349; -.
DR   HOGENOM; CLU_167264_0_0_1; -.
DR   InParanoid; Q9QXQ6; -.
DR   OMA; PQMSDQD; -.
DR   OrthoDB; 1502468at2759; -.
DR   PhylomeDB; Q9QXQ6; -.
DR   TreeFam; TF339481; -.
DR   PRO; PR:Q9QXQ6; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000022129; Expressed in thymus and 1 other tissue.
DR   Genevisible; Q9QXQ6; RN.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0042595; P:behavioral response to starvation; ISO:RGD.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0032098; P:regulation of appetite; ISO:RGD.
DR   GO; GO:0009725; P:response to hormone; IEP:RGD.
DR   GO; GO:0032868; P:response to insulin; IEP:RGD.
DR   InterPro; IPR008174; Galanin.
DR   InterPro; IPR039244; GALP.
DR   PANTHER; PTHR20950; PTHR20950; 1.
DR   Pfam; PF01296; Galanin; 1.
DR   PROSITE; PS00861; GALANIN; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..83
FT                   /note="Galanin-like peptide"
FT                   /id="PRO_0000010467"
FT   PROPEP          86..115
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000010468"
SQ   SEQUENCE   115 AA;  12600 MW;  00BD3A2336AD06C5 CRC64;
     MACSKHLVLF LTILLSLAET PDSAPAHRGR GGWTLNSAGY LLGPVLHLSS KANQGRKTDS
     ALEILDLWKA IDGLPYSRSP RMTKRSMGET FVKPRTGDLR IVDKNVPDEE ATLNL