GALR1_RAT
ID GALR1_RAT Reviewed; 346 AA.
AC Q62805;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Galanin receptor type 1;
DE Short=GAL1-R;
DE Short=GALR-1;
GN Name=Galr1; Synonyms=Galnr, Galnr1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Insulinoma;
RX PubMed=8750821; DOI=10.1016/0169-328x(95)00159-p;
RA Parker E.M., Izzarelli D.G., Nowak H.P., Mahle C.D., Iben L.G., Wang J.,
RA Goldstein M.E.;
RT "Cloning and characterization of the rat GALR1 galanin receptor from Rin14B
RT insulinoma cells.";
RL Brain Res. Mol. Brain Res. 34:179-189(1995).
CC -!- FUNCTION: Receptor for the hormone galanin. The activity of this
CC receptor is mediated by G proteins that inhibit adenylate cyclase
CC activity. {ECO:0000250|UniProtKB:P47211, ECO:0000269|PubMed:8750821}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Spinal cord, small intestine, Rin14B insulinoma
CC cells and several brain regions, particularly ventral hippocampus,
CC amygdala, supraoptic nucleus, hypothalamus, thalamus, lateral
CC parabrachial nucleus and locus coeruleus. {ECO:0000269|PubMed:8750821}.
CC -!- PTM: Three cysteine residues are found in the C-terminus, at least one
CC of which may be palmitoylated.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U30290; AAC52438.1; -; mRNA.
DR RefSeq; NP_037090.2; NM_012958.3.
DR AlphaFoldDB; Q62805; -.
DR SMR; Q62805; -.
DR STRING; 10116.ENSRNOP00000022400; -.
DR BindingDB; Q62805; -.
DR ChEMBL; CHEMBL5504; -.
DR GuidetoPHARMACOLOGY; 243; -.
DR GlyGen; Q62805; 3 sites.
DR PhosphoSitePlus; Q62805; -.
DR PaxDb; Q62805; -.
DR Ensembl; ENSRNOT00000022401; ENSRNOP00000022400; ENSRNOG00000016654.
DR GeneID; 50577; -.
DR KEGG; rno:50577; -.
DR CTD; 2587; -.
DR RGD; 2656; Galr1.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244841; -.
DR HOGENOM; CLU_009579_6_4_1; -.
DR InParanoid; Q62805; -.
DR OMA; LPHHIIH; -.
DR OrthoDB; 1294084at2759; -.
DR PhylomeDB; Q62805; -.
DR TreeFam; TF315737; -.
DR Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:Q62805; -.
DR Proteomes; UP000002494; Chromosome 18.
DR Bgee; ENSRNOG00000016654; Expressed in jejunum and 5 other tissues.
DR Genevisible; Q62805; RN.
DR GO; GO:0016021; C:integral component of membrane; TAS:RGD.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0004966; F:galanin receptor activity; IDA:RGD.
DR GO; GO:0042923; F:neuropeptide binding; IDA:RGD.
DR GO; GO:0017046; F:peptide hormone binding; ISS:UniProtKB.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IMP:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:RGD.
DR GO; GO:0007194; P:negative regulation of adenylate cyclase activity; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0051464; P:positive regulation of cortisol secretion; ISO:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR InterPro; IPR003906; GAL1_rcpt.
DR InterPro; IPR000405; Galanin_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01418; GALANIN1R.
DR PRINTS; PR00663; GALANINR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..346
FT /note="Galanin receptor type 1"
FT /id="PRO_0000069465"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..346
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 326..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 318
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 181
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 107..185
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 346 AA; 38862 MW; 789FFBE40D1D3805 CRC64;
MELAPVNLSE GNGSDPEPPA EPRPLFGIGV ENFITLVVFG LIFAMGVLGN SLVITVLARS
KPGKPRSTTN LFILNLSIAD LAYLLFCIPF QATVYALPTW VLGAFICKFI HYFFTVSMLV
SIFTLAAMSV DRYVAIVHSR RSSSLRVSRN ALLGVGFIWA LSIAMASPVA YYQRLFHRDS
NQTFCWEHWP NQLHKKAYVV CTFVFGYLLP LLLICFCYAK VLNHLHKKLK NMSKKSEASK
KKTAQTVLVV VVVFGISWLP HHVIHLWAEF GAFPLTPASF FFRITAHCLA YSNSSVNPII
YAFLSENFRK AYKQVFKCRV CNESPHGDAK EKNRIDTPPS TNCTHV