GALR3_RAT
ID GALR3_RAT Reviewed; 370 AA.
AC O88626; O54914; Q9QWZ2;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=Galanin receptor type 3;
DE Short=GAL3-R;
DE Short=GALR-3;
GN Name=Galr3; Synonyms=Galnr3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Hypothalamus;
RX PubMed=10619483; DOI=10.1016/s0306-4522(99)00407-8;
RA Waters S.M., Krause J.E.;
RT "Distribution of galanin-1, -2 and -3 receptor messenger RNAs in central
RT and peripheral rat tissues.";
RL Neuroscience 95:265-271(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Wang S., He C., Hashemi T., Bayne M.;
RT "Molecular cloning of the rat galanin receptor type 3.";
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=Sprague-Dawley;
RX PubMed=9722565; DOI=10.1074/jbc.273.36.23321;
RA Smith K.E., Walker M.W., Artymyshyn R., Bard J., Borowsky B., Tamm J.A.,
RA Yao W.-J., Vaysse P.J.-J., Branchek T.A., Gerald C., Jones K.A.;
RT "Cloned human and rat galanin GALR3 receptors: pharmacology and activation
RT of G-protein inwardly rectifying K+ channels.";
RL J. Biol. Chem. 273:23321-23326(1998).
CC -!- FUNCTION: Receptor for the hormone galanin and spexin-1.
CC {ECO:0000250|UniProtKB:O60755, ECO:0000269|PubMed:9722565}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF079844; AAC34590.1; -; mRNA.
DR EMBL; AF031522; AAC26145.1; -; mRNA.
DR EMBL; AF073798; AAC35943.1; -; mRNA.
DR RefSeq; NP_062046.1; NM_019173.1.
DR RefSeq; XP_006242034.1; XM_006241972.2.
DR RefSeq; XP_017450186.1; XM_017594697.1.
DR AlphaFoldDB; O88626; -.
DR SMR; O88626; -.
DR STRING; 10116.ENSRNOP00000014349; -.
DR BindingDB; O88626; -.
DR GuidetoPHARMACOLOGY; 245; -.
DR GlyGen; O88626; 1 site.
DR PhosphoSitePlus; O88626; -.
DR PaxDb; O88626; -.
DR GeneID; 29235; -.
DR KEGG; rno:29235; -.
DR UCSC; RGD:2658; rat.
DR CTD; 8484; -.
DR RGD; 2658; Galr3.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; O88626; -.
DR OrthoDB; 1294084at2759; -.
DR PhylomeDB; O88626; -.
DR Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:O88626; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005929; C:cilium; ISO:RGD.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0097730; C:non-motile cilium; ISO:RGD.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0004966; F:galanin receptor activity; IDA:MGI.
DR GO; GO:0017046; F:peptide hormone binding; ISS:UniProtKB.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; ISO:RGD.
DR GO; GO:0090663; P:galanin-activated signaling pathway; ISO:RGD.
DR GO; GO:0007194; P:negative regulation of adenylate cyclase activity; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR InterPro; IPR000405; Galanin_rcpt.
DR InterPro; IPR003908; Galnin_3_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01420; GALANIN3R.
DR PRINTS; PR00663; GALANINR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..370
FT /note="Galanin receptor type 3"
FT /id="PRO_0000069471"
FT TOPO_DOM 1..20
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..184
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..259
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..370
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 317..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 308
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 54
FT /note="R -> S (in Ref. 3; AAC35943)"
FT /evidence="ECO:0000305"
FT CONFLICT 127
FT /note="P -> Q (in Ref. 2; AAC26145)"
FT /evidence="ECO:0000305"
FT CONFLICT 183
FT /note="A -> R (in Ref. 2; AAC26145)"
FT /evidence="ECO:0000305"
FT CONFLICT 311
FT /note="R -> C (in Ref. 2; AAC26145)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 370 AA; 40410 MW; CE5B39E6147AFAD4 CRC64;
MADIQNISLD SPGSVGAVAV PVIFALIFLL GMVGNGLVLA VLLQPGPSAW QEPRSTTDLF
ILNLAVADLC FILCCVPFQA AIYTLDAWLF GAFVCKTVHL LIYLTMYASS FTLAAVSLDR
YLAVRHPLRS RALRTPRNAR AAVGLVWLLA ALFSAPYLSY YGTVRYGALE LCVPAWEDAR
RRALDVATFA AGYLLPVAVV SLAYGRTLCF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV
AALYALCWGP HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YSLASRHFRA
RFRRLWPCGR RRHRHHHRAH RALRRVQPAS SGPAGYPGDA RPRGWSMEPR GDALRGGGET
RLTLSPRGPQ
