GALR_HAEIN
ID GALR_HAEIN Reviewed; 332 AA.
AC P31766;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=HTH-type transcriptional regulator GalR;
DE AltName: Full=Galactose operon repressor;
GN Name=galR; Synonyms=galS; OrderedLocusNames=HI_0821;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=RM 7004 / Serotype B;
RX PubMed=1282642; DOI=10.1111/j.1365-2958.1992.tb01763.x;
RA Maskell D.J., Szabo M.J., Deadman M.E., Moxon E.R.;
RT "The gal locus from Haemophilus influenzae: cloning, sequencing and the use
RT of gal mutants to study lipopolysaccharide.";
RL Mol. Microbiol. 6:3051-3063(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Repressor of the galactose operon. Binds galactose as an
CC inducer.
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism [regulation].
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DR EMBL; X65934; CAA46729.1; -; Genomic_DNA.
DR EMBL; L42023; AAC22480.1; -; Genomic_DNA.
DR PIR; F64096; F64096.
DR RefSeq; NP_438981.1; NC_000907.1.
DR RefSeq; WP_005663077.1; NC_000907.1.
DR AlphaFoldDB; P31766; -.
DR SMR; P31766; -.
DR STRING; 71421.HI_0821; -.
DR EnsemblBacteria; AAC22480; AAC22480; HI_0821.
DR KEGG; hin:HI_0821; -.
DR PATRIC; fig|71421.8.peg.862; -.
DR eggNOG; COG1609; Bacteria.
DR HOGENOM; CLU_037628_6_0_6; -.
DR OMA; CVAVDFR; -.
DR PhylomeDB; P31766; -.
DR BioCyc; HINF71421:G1GJ1-862-MON; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd01392; HTH_LacI; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR PRINTS; PR00036; HTHLACI.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW Carbohydrate metabolism; DNA-binding; Galactose metabolism;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..332
FT /note="HTH-type transcriptional regulator GalR"
FT /id="PRO_0000107953"
FT DOMAIN 1..56
FT /note="HTH lacI-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT DNA_BIND 4..23
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT CONFLICT 35
FT /note="V -> A (in Ref. 1; CAA46729)"
FT /evidence="ECO:0000305"
FT CONFLICT 38
FT /note="Q -> R (in Ref. 1; CAA46729)"
FT /evidence="ECO:0000305"
FT CONFLICT 208
FT /note="P -> L (in Ref. 1; CAA46729)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 332 AA; 36708 MW; 0F431000946AF8A5 CRC64;
MSTIRDVAKL ANVSVATVSR VLNHSLSVSE NTRLVVEQAI AQLAYQPNAN AQALAVQNTD
TIGVVVTDVT DAFFAILVKA VDKVAEAHQK TILIGIGYHH AEKEREAINT LLRKRCSSLV
VHSKALSDDE LSHYLNTVQG MVIINRVIKG YEHRCVSLDN QKGTYLATEM LIRYGHQHIA
YIGSNHAIFD EVERRNGYLA ALKDHNYPII EQAITLNSPD FEGGEKAMID LLSYNKNLTA
VVAYNDSMAA GAISVLNENN ISVPSQFSII GFDDMPIARY LIPKLTTIRY PIDLMATYAA
KLALSLTDEK IITPPVVQFN PTLVRRFSVE SR
