ID   GALR_LACCA              Reviewed;         331 AA.
AC   O84905;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=HTH-type transcriptional regulator GalR;
DE   AltName: Full=Galactose operon repressor;
GN   Name=galR;
OS   Lactobacillus casei.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=1582;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=64H;
RX   PubMed=9603808; DOI=10.1128/aem.64.6.2013-2019.1998;
RA   Bettenbrock K., Alpert C.-A.;
RT   "The gal genes for the Leloir pathway of Lactobacillus casei 64H.";
RL   Appl. Environ. Microbiol. 64:2013-2019(1998).
CC   -!- FUNCTION: Repressor of the galactose operon. Binds galactose as an
CC       inducer (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism [regulation].
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DR   EMBL; AF005933; AAC19331.1; -; Genomic_DNA.
DR   AlphaFoldDB; O84905; -.
DR   SMR; O84905; -.
DR   STRING; 543734.LCABL_07330; -.
DR   eggNOG; COG1609; Bacteria.
DR   UniPathway; UPA00214; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; DNA-binding; Galactose metabolism; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..331
FT                   /note="HTH-type transcriptional regulator GalR"
FT                   /id="PRO_0000107954"
FT   DOMAIN          1..58
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   331 AA;  36479 MW;  21D5C84DB33AFD63 CRC64;
     MTTITDIAKA AGVSIATVSR ILNYDTTLAV TPETRQRVLK TAEKLAYKPR RRKRVSPQTT
     VALIQWRSEQ EELNDLYYLQ IQYAIEARAA SAGYHLQSLH LEQLAAETTQ NVQGVIALGK
     YDAGEVATIK ALAQPVVFVD QNMLAFDCDS VTSDYAGPIE QIIHHFQSVG INDIGFLGGV
     ETSRSGREQF QDVRTAAFDR VMHAENLMQP AFRFIGAFTP DSGYELMKQA ITKLGDTLPH
     GFIVANDTMA VGALRALNEA KIEVPQRVSV ISFNDVAVAK FTTPPLSTVH AATDQMGQTA
     VELLQARIKD PKRIPRQVNF KSELIMRASS L