ID   GALR_SALTS              Reviewed;         342 AA.
AC   E1WAQ4; P74866;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=HTH-type transcriptional regulator GalR;
DE   AltName: Full=Galactose operon repressor;
GN   Name=galR; OrderedLocusNames=SL1344_2989;
OS   Salmonella typhimurium (strain SL1344).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=216597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL1344;
RX   PubMed=22538806; DOI=10.1073/pnas.1201061109;
RA   Kroger C., Dillon S.C., Cameron A.D., Papenfort K., Sivasankaran S.K.,
RA   Hokamp K., Chao Y., Sittka A., Hebrard M., Handler K., Colgan A.,
RA   Leekitcharoenphon P., Langridge G.C., Lohan A.J., Loftus B., Lucchini S.,
RA   Ussery D.W., Dorman C.J., Thomson N.R., Vogel J., Hinton J.C.;
RT   "The transcriptional landscape and small RNAs of Salmonella enterica
RT   serovar Typhimurium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:E1277-E1286(2012).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-71.
RC   STRAIN=SL1344;
RX   PubMed=8930920; DOI=10.1046/j.1365-2958.1996.00120.x;
RA   Valdivia R.H., Falkow S.;
RT   "Bacterial genetics by flow cytometry: rapid isolation of Salmonella
RT   typhimurium acid-inducible promoters by differential fluorescence
RT   induction.";
RL   Mol. Microbiol. 22:367-378(1996).
CC   -!- FUNCTION: Repressor of the galactose operon. Binds galactose as an
CC       inducer (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism [regulation].
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR   EMBL; FQ312003; CBW19088.1; -; Genomic_DNA.
DR   EMBL; U62708; AAC44601.1; -; Genomic_DNA.
DR   RefSeq; WP_000201030.1; NZ_QASL01000005.1.
DR   AlphaFoldDB; E1WAQ4; -.
DR   SMR; E1WAQ4; -.
DR   EnsemblBacteria; CBW19088; CBW19088; SL1344_2989.
DR   KEGG; sey:SL1344_2989; -.
DR   PATRIC; fig|216597.6.peg.3333; -.
DR   HOGENOM; CLU_037628_6_0_6; -.
DR   OMA; CVAVDFR; -.
DR   BioCyc; SENT216597:SL1344_RS15580-MON; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000008962; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; DNA-binding; Galactose metabolism; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..342
FT                   /note="HTH-type transcriptional regulator GalR"
FT                   /id="PRO_0000405422"
FT   DOMAIN          1..56
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   342 AA;  36869 MW;  7410957D4BA5A6E0 CRC64;
     MATIKDVARL AGVSVATVSR VINDSPKASE ASRLAVTSAM ESLSYHPNAN ARALAQQATE
     TLGLVVGDVS DPFFGAMVKA VEQVAYHTGN FLLIGNGYHN EQKERQAIEQ LIRHRCAALV
     VHAKMIPDAD LASLMKQIPG MVLINRILPG LEHRCVALDD RYGAWLATRH LIQQGHTRIG
     YICSNHTISD AEDRLRGYYD ALAESHIPAN DRLVTFGEPD ESGGEQAMTE LLGRGRNFTA
     VACYNDSMAA GAMGVLNDNG VGVPGEVSLI GFDDVLVSRY VRPRLTTIRY PIVTMATQAA
     ELALALAGKC PTPEVTHVFS PTLVRRHSVS TPTDTGHLST TD