ID   GALR_SALTY              Reviewed;         342 AA.
AC   P0CL11; P74866;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=HTH-type transcriptional regulator GalR;
DE   AltName: Full=Galactose operon repressor;
GN   Name=galR; OrderedLocusNames=STM3011;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Repressor of the galactose operon. Binds galactose as an
CC       inducer (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism [regulation].
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR   EMBL; AE006468; AAL21887.1; -; Genomic_DNA.
DR   RefSeq; NP_461928.1; NC_003197.2.
DR   RefSeq; WP_000201030.1; NC_003197.2.
DR   AlphaFoldDB; P0CL11; -.
DR   SMR; P0CL11; -.
DR   STRING; 99287.STM3011; -.
DR   PaxDb; P0CL11; -.
DR   EnsemblBacteria; AAL21887; AAL21887; STM3011.
DR   GeneID; 1254534; -.
DR   KEGG; stm:STM3011; -.
DR   PATRIC; fig|99287.12.peg.3187; -.
DR   HOGENOM; CLU_037628_6_0_6; -.
DR   OMA; CVAVDFR; -.
DR   PhylomeDB; P0CL11; -.
DR   BioCyc; SENT99287:STM3011-MON; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; DNA-binding; Galactose metabolism;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..342
FT                   /note="HTH-type transcriptional regulator GalR"
FT                   /id="PRO_0000107952"
FT   DOMAIN          1..56
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   342 AA;  36869 MW;  7410957D4BA5A6E0 CRC64;
     MATIKDVARL AGVSVATVSR VINDSPKASE ASRLAVTSAM ESLSYHPNAN ARALAQQATE
     TLGLVVGDVS DPFFGAMVKA VEQVAYHTGN FLLIGNGYHN EQKERQAIEQ LIRHRCAALV
     VHAKMIPDAD LASLMKQIPG MVLINRILPG LEHRCVALDD RYGAWLATRH LIQQGHTRIG
     YICSNHTISD AEDRLRGYYD ALAESHIPAN DRLVTFGEPD ESGGEQAMTE LLGRGRNFTA
     VACYNDSMAA GAMGVLNDNG VGVPGEVSLI GFDDVLVSRY VRPRLTTIRY PIVTMATQAA
     ELALALAGKC PTPEVTHVFS PTLVRRHSVS TPTDTGHLST TD