ID   GALR_STRTR              Reviewed;         331 AA.
AC   Q9ZB11;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=HTH-type transcriptional regulator GalR;
DE   AltName: Full=Galactose operon repressor;
GN   Name=galR;
OS   Streptococcus thermophilus.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CNRZ 302;
RX   PubMed=11157930; DOI=10.1128/jb.183.4.1184-1194.2001;
RA   Vaughan E.E., van den Bogaard P.T.C., Catzeddu P., Kuipers O.P.,
RA   de Vos W.M.;
RT   "Activation of silent gal genes in the lac-gal regulon of Streptococcus
RT   thermophilus.";
RL   J. Bacteriol. 183:1184-1194(2001).
CC   -!- FUNCTION: Repressor of the galactose operon. Binds galactose as an
CC       inducer (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism [regulation].
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DR   EMBL; U61402; AAD00092.1; -; Genomic_DNA.
DR   RefSeq; WP_011226273.1; NZ_WMLD01000001.1.
DR   AlphaFoldDB; Q9ZB11; -.
DR   SMR; Q9ZB11; -.
DR   STRING; 322159.STER_1372; -.
DR   GeneID; 66899167; -.
DR   eggNOG; COG1609; Bacteria.
DR   OMA; VYTEFMG; -.
DR   UniPathway; UPA00214; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; DNA-binding; Galactose metabolism; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..331
FT                   /note="HTH-type transcriptional regulator GalR"
FT                   /id="PRO_0000107955"
FT   DOMAIN          1..62
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   331 AA;  37152 MW;  EAC8BCB1D5D27D48 CRC64;
     MATLADIAKL AGVSISTVSR VLNKDETLSV TEDTRHRILT IADEIGYTKY KTINNSKKEK
     YQVAIIQWVS EEHELDDIYY YNIRLGIEKR AYELDYEMLH FFNDIPSSLG EEVVGVLCIG
     KFSREQIAKL ERLKKTLVFV DSDTLNQGHP CVTTDFENSV QSALCYLKEQ GCNNIGLLIG
     QEKTTDATEI ISDPRLRSYR NYCMEKGIYD PLFILTGDFT VQSGYELLDS KIKSGATLPD
     AYFAASDSLA IGALRALQEN GIKVPDDIQI ISFNDTTLAK QVYPPLSSVT VYTEEMGRTA
     MDILNKQLLA PRKIPTLTKL GTKLTLRNST K